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製品番号: HY-148771

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MTX-23

(別名: PROTAC AR-V7 degrader-2)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.
(Pink: AR-V7 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.79%
CAS 番号: 2488296-74-6
分子式: C₄₃H₅₃F₂N₇O₇S₂
分子量:882.05

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MTX-23 構造式

CAS 番号: 2488296-74-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis^[1]. (Pink: AR-V7 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).

PROTACs アイソフォーム固有の製品をすべて表示 :

体外実験

MTX-23 (compound 16; 0-20 μM; 4 d; 22Rvl cells) inhibits cell growth in dose-dependent manner^[1].
MTX-23 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels^[1].
MTX-23 (1 μM; 0-48 h; 22Rvl cells) induces apoptosis and increases annexin-V staining^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

22Rvl cells
Concentration:

0-20 μM
Incubation Time:

4 days
Result:

Reduced the cell count by less than 50 percent.

Apoptosis Analysis^[1]

Cell Line:

22Rvl cells
Concentration:

1 μM
Incubation Time:

0-48 h
Result:

Induced cell apoptosis in 22Rvl cells.

Western Blot Analysis^[1]

Cell Line:

22Rvl cells
Concentration:

10 μM
Incubation Time:

4 days
Result:

Reduced AR-V7 protein levels.

体内実験

MTX-23 (compound 16; 2.5 mg/mL; intratumor injection) inhibits tumor growth in nu/nu mice with 22Rvl-Enz^R tumor xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

nu/nu mice with 22Rvl-Enz^R tumor xenografts^[1]
Dosage:

2.5 mg/mL
Administration:

intratumor injection
Result:

Inhibited tumor growth in nu/nu mice with 22Rvl-Enz^R tumor xenografts.

化学情報

CAS 番号 2488296-74-6
性状 Solid
分子量 882.05
分子式 C₄₃H₅₃F₂N₇O₇S₂
Color Off-white to light yellow
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
別名

PROTAC AR-V7 degrader-2
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Nature

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma. [Abstract]

2026 Apr;652(8110):763-773. PMID: 41882358

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (113.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1337 mL

5.6686 mL

11.3372 mL

5 mM

0.2267 mL

1.1337 mL

2.2674 mL

10 mM

0.1134 mL

0.5669 mL

1.1337 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jenny D, et, al. Bi-functional compounds and methods for targeted ubiquitination of androgen receptor. WO2021236695.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1337 mL	5.6686 mL	11.3372 mL	28.3431 mL
	5 mM	0.2267 mL	1.1337 mL	2.2674 mL	5.6686 mL
	10 mM	0.1134 mL	0.5669 mL	1.1337 mL	2.8343 mL
	15 mM	0.0756 mL	0.3779 mL	0.7558 mL	1.8895 mL
	20 mM	0.0567 mL	0.2834 mL	0.5669 mL	1.4172 mL
	25 mM	0.0453 mL	0.2267 mL	0.4535 mL	1.1337 mL
	30 mM	0.0378 mL	0.1890 mL	0.3779 mL	0.9448 mL
	40 mM	0.0283 mL	0.1417 mL	0.2834 mL	0.7086 mL
	50 mM	0.0227 mL	0.1134 mL	0.2267 mL	0.5669 mL
	60 mM	0.0189 mL	0.0945 mL	0.1890 mL	0.4724 mL
	80 mM	0.0142 mL	0.0709 mL	0.1417 mL	0.3543 mL
	100 mM	0.0113 mL	0.0567 mL	0.1134 mL	0.2834 mL

Keywords

MTX-23

1 Cited Publications

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MTX-23

Apoptosis Compound Library

Anti-Cancer Compound Library

Transcription Factor-Targeted Library

Anti-Prostate Cancer Compound Library

Nuclear Receptor Compound Library

PROTAC Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

MedChemExpress（MCE）の使用を引用している文献 MTX-23

PROTACs アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

MTX-23

Apoptosis Compound Library

Anti-Cancer Compound Library

Transcription Factor-Targeted Library

Anti-Prostate Cancer Compound Library

Nuclear Receptor Compound Library

PROTAC Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

MedChemExpress（MCE）の使用を引用している文献 MTX-23

PROTACs アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

MTX-23 関連分類

製品番号: HY-148771