MTX-23
Based on 1 publication(s) in Google Scholar
MTX-23 is a PROTAC degrader targeting androgen receptor splice variant 7 (AR-V7) and full-length androgen receptor (AR-FL), with DC50 values of 0.37 μM and 2 μM, respectively. MTX-23 binds to the DNA-binding domains of AR-V7 and AR-FL, recruits the VHL E3 ubiquitin ligase (E3 ubiquitin ligase) and induces their degradation. MTX-23 reduces the proliferation of prostate cancer cells, promotes their apoptosis (apoptosis), and also inhibits tumor growth in mouse models. MTX-23 can be used for the research of prostate cancer.
(Pink: AR-V7 ligand (HY-175939); Blue: VHL ligand (HY-112078); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.79%
- CAS 番号: 2488296-74-6
- 分子式: C43H53F2N7O7S2
- 分子量:882.05
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 MTX-23
MorePROTACs アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
AR-V7 0.37 μM (DC50) |
AR-FL 2 μM (DC50) |
体外実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Detection of Apoptosis
- TUNEL staining for apoptotic DNA fragmentation
- Annexin V plus membrane-impermeant dye apoptosis staining
- Research Protocol for Endocrine Diseases
- Patient-Derived Xenograft (PDX)
- Apoptosis Solutions
- Patient-Derived Orthotopic Xenograft (PDOX)
- Subcutaneous Cell-Line-Derived Xenograft
- Orthotopic Cell-Line Xenograft
- Cell Viability Determination by MTT Colorimetric Assay
化学情報
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CAS 番号 2488296-74-6
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性状 Solid
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分子量 882.05
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分子式 C43H53F2N7O7S2
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Color Off-white to light yellow
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SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
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別名
PROTAC AR-V7 degrader-2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nature
2026 Apr;652(8110):763-773. PMID: 41882358
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (113.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1337 mL | 5.6686 mL | 11.3372 mL | 28.3431 mL |
| 5 mM | 0.2267 mL | 1.1337 mL | 2.2674 mL | 5.6686 mL | |
| 10 mM | 0.1134 mL | 0.5669 mL | 1.1337 mL | 2.8343 mL | |
| 15 mM | 0.0756 mL | 0.3779 mL | 0.7558 mL | 1.8895 mL | |
| 20 mM | 0.0567 mL | 0.2834 mL | 0.5669 mL | 1.4172 mL | |
| 25 mM | 0.0453 mL | 0.2267 mL | 0.4535 mL | 1.1337 mL | |
| 30 mM | 0.0378 mL | 0.1890 mL | 0.3779 mL | 0.9448 mL | |
| 40 mM | 0.0283 mL | 0.1417 mL | 0.2834 mL | 0.7086 mL | |
| 50 mM | 0.0227 mL | 0.1134 mL | 0.2267 mL | 0.5669 mL | |
| 60 mM | 0.0189 mL | 0.0945 mL | 0.1890 mL | 0.4724 mL | |
| 80 mM | 0.0142 mL | 0.0709 mL | 0.1417 mL | 0.3543 mL | |
| 100 mM | 0.0113 mL | 0.0567 mL | 0.1134 mL | 0.2834 mL |
MTX-23 関連分類
HY-148771 関連分類
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Keywords
- MTX-23
- 2488296-74-6
- PROTAC AR-V7 degrader-2
- MTX23
- MTX 23
- PROTACs
- Androgen Receptor
- Apoptosis
- AR-V7
- Androgen Receptor Full-Length
- Androgen Receptor Splice Variant-7
- prostate cancer cells
- mouse models
- Von Hippel-Lindau E3 ubiquitin ligase
- AR-FL
- androgen-responsive prostate cancer cells
- human prostate cancer cell lines
- castration-resistant prostate cancer
- Inhibitor
- inhibitor
- inhibit