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製品番号: HY-123699

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NCT-10b

NCT-10b is a selective HDAC6 inhibitor. NCT-10b mediates preferential α-tubulin acetylation without major histone H4 acetylation.NCT-10b can be used for the research of multiple myeloma.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 908860-09-3
分子式: C₂₁H₃₈N₂O₄S
分子量:414.61

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NCT-10b 構造式

CAS 番号: 908860-09-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

NCT-10b is a selective HDAC6 inhibitor. NCT-10b mediates preferential α-tubulin acetylation without major histone H4 acetylation.NCT-10b can be used for the research of multiple myeloma^[1].

IC₅₀ & Target^[1]

HDAC6

α-Tubulin

HDAC アイソフォーム固有の製品をすべて表示 :

体外実験

NCT-10b (compound 17b) (0.1-300 μM; 8 h) selectively induces α-tubulin acetylation over histone H4 acetylation in HCT116 cells, with an EC₅₀ of 0.23 μM for α-tubulin acetylation and a selectivity index >140^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

0.1; 0.3; 1; 3; 10; 30; 100; 300 μM
Incubation Time:

8 h
Result:

Produced a dose-dependent increase in acetylated α-tubulin without a major increase in acetylated histone H4.
Reached an EC₅₀ value of 0.23 μM for α-tubulin acetylation, and an EC₅₀ value of >32 μM for histone H4 acetylation, resulting in a selectivity index of >140.

化学情報

CAS 番号 908860-09-3
分子量 414.61
分子式 C₂₁H₃₈N₂O₄S
SMILES

[C@H](C(NC1CCCC1)=O)(NC(OC(C)(C)C)=O)CCCCCSC(C(C)C)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Suzuki T, et al. Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate. J Med Chem. 2006;49(16):4809-4812. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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NCT-10b

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