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製品番号: HY-P991271

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NN-8828

(別名: NNC-114-0005; NN9828; NNC01140006)

カスタマーレビュー

Based on 1 Customer Validation

NN-8828 (NNC-114-0005; NN9828; NNC01140006) is a human IgG1 monoclonal antibody inhibitor targeting IL-21 that binds and neutralizes soluble IL-21 with a K_d of 0.19 pM. NN-8828 restores the balance between effector T cells and regulatory T cells, inhibits pathological antibody production, and alleviates IL-21-mediated inflammatory responses without inducing antibody-dependent cellular cytotoxicity. NN-8828 exhibits favorable biosafety. NN-8828 can be used in research related to rheumatoid arthritis, type 1 diabetes, and systemic lupus erythematosus.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 97.89%
分子量:145.12 kDa

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NN-8828 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

IL-21

Interleukin Related アイソフォーム固有の製品をすべて表示 :

体外実験

NN-8828 neutralizes IL-21 in unspecified cell-based systems with an IC₅₀ in the sub- or low nanomolar range^[1].
NN-8828 binds to soluble IL-21 with a high affinity, having a K_d of 0.19 pM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

NN-8828 (i.v.; repeat-dose; up to 39 weeks) does not cause adverse effects on the reproductive organs of cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

遺伝子ID

59067 [NCBI]

アクセッション番号

Q9HBE4

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

アプリケーション

ELISA, FACS, Functional assay

化学情報

性状 Liquid
分子量 145.12 kDa
Color colorless
SMILES

[NN-8828]
別名

NNC-114-0005; NN9828; NNC01140006
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (258 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Novo Nordisk A/S. A randomised, double-blind, double-dummy, placebo-controlled, parallel-group, multi-centre clinical proof-of-principle trial in adult subjects with newly diagnosed type 1 diabetes mellitus investigating the effect of NNC0114-0006 and liraglutide on preservation of beta-cell function. ClinicalTrials.gov Identifier: NCT02443155. Sponsor Trial ID: NN9828-4150. Document date: 17 September 2019.

[2]. Cañete J D, et al. Efficacy and Safety of NNC01140006, an Anti-IL-21 Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis.: 947[J]. Arthritis & Rheumatology, 2014, 66: S421.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
CAS 番号:
生物種:
純度:
数量:

NN-8828

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

Interleukin Related アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

NN-8828 関連分類

HY-P991271 関連分類