Nogalamycin
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Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.2%
- CAS 番号: 1404-15-5
- 分子式: C39H49NO16
- 分子量:787.80
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
RNA Synthesis[2]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
59 μM
Compound: Nogalamycin
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Cytotoxicity in human leukemic CCRF-CEM cells.
Cytotoxicity in human leukemic CCRF-CEM cells.
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[PMID: 14667232] |
Nogalamycin (0-10 μg/ml; 2 hours) exhibits lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CHO, L1210 and B16 cells[1]
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Concentration:0-10 μg/ml
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Incubation Time:2 hours
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Result:Exhibited lethality against CHO, L1210 and B16 with LD50s of 2.74 μg/ml, 0.25 μg/ml and 0.15 μg/ml.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats[1]
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Dosage:0-1000 mug/kg
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Administration:IP
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Result:Regressed chemically-induced fibrosarcoma tumors and tumors of spontaneous origin in rats, and the most effective concentration was 556 mug/kg.
化学情報
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CAS 番号 1404-15-5
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性状 Solid
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分子量 787.80
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分子式 C39H49NO16
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Color Orange to red
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SMILES
O=C1C2=C(C(C3=C1C=C4C([C@H](C[C@](C)(O)[C@@H]4C(OC)=O)O[C@@]5([H])[C@@H]([C@@](C)([C@@H](OC)[C@H](C)O5)OC)OC)=C3O)=O)C(O)=CC6=C2O[C@]([C@@H](O)[C@H](N(C)C)[C@H]7O)([H])O[C@]67C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 10 mg/mL (12.69 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Bhuyan BK, et al. Cell kill kinetics of several nogalamycin analogs and adriamycin for Chinese hamster ovary, L1210 leukemia, and B16 melanoma cells in culture. Cancer Res. 1981;41(1):18-24. [Content Brief]
[2]. Bhuyan BK, et al. Differential interaction of nogalamycin with DNA of varying base composition. Proc Natl Acad Sci U S A. 1965;54(2):566-572. [Content Brief]
[3]. Bempong MA. Cytological effect of nogalamycin in mammals and regression of methylcholanthrene-induced and spontaneous tumors in rats. Int J Clin Pharmacol Biopharm. 1976;14(1):6-14. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2694 mL | 6.3468 mL | 12.6936 mL | 31.7339 mL |
| 5 mM | 0.2539 mL | 1.2694 mL | 2.5387 mL | 6.3468 mL | |
| 10 mM | 0.1269 mL | 0.6347 mL | 1.2694 mL | 3.1734 mL |
Nogalamycin 関連分類
HY-105846 関連分類
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