製品番号: HY-N0428

オバクノン

(別名: Obacunone)

4 Cited Publications

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage.

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純度: 99.75%
CAS 番号: 751-03-1
分子式: C₂₆H₃₀O₇
分子量:454.51

保管条件:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Obacunone 構造式

CAS 番号: 751-03-1

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (4)
溶剤 & 溶解度
- 体外
- 体内
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	IC₅₀	83.61 μM Compound: 5	Antiinflammatory activity in mouse J774A1 cells assessed as reduction of LPS-induced nitric oxide production treated 2 hrs before LPS addition measured after 20 hrs by using Griess reagent Antiinflammatory activity in mouse J774A1 cells assessed as reduction of LPS-induced nitric oxide production treated 2 hrs before LPS addition measured after 20 hrs by using Griess reagent	[PMID: 23688954]
MCF7	IC₅₀	0.02 μM Compound: 11g	Antiproliferative activity against human MCF7 cells incubated for 48 hrs by [3H]-thymidine incorporation assay Antiproliferative activity against human MCF7 cells incubated for 48 hrs by [3H]-thymidine incorporation assay	[PMID: 33289552]
MDA-MB-435	IC₅₀	6.8 μM Compound: 11g	Antiproliferative activity against human MDA-MB-435 cells incubated for 48 hrs by [3H]-thymidine incorporation assay Antiproliferative activity against human MDA-MB-435 cells incubated for 48 hrs by [3H]-thymidine incorporation assay	[PMID: 33289552]
SW480	IC₅₀	56 μM Compound: 11g	Antiproliferative activity against human SW480 cells incubated for 72 hrs by MTT assay Antiproliferative activity against human SW480 cells incubated for 72 hrs by MTT assay	[PMID: 33289552]

体外実験

Obacunone (1-50 μM; 48 h) effectively inhibits UVR-induced cytotoxicity^[2].
Obacunone (25 μM; 1 h+12 h) improves UVR-induced oxidative damage in ARPE-19 cells and inhibits reactive oxygen species accumulation, mitochondrial depolarization, lipid peroxidation, and single-stranded DNA accumulation in human ARPE-19 cells^[2].
Obacunone (25 μM; 1 h+12 h) slows UVR-induced apoptosis in human ARPE-19 cells and murine RPE cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Obacunone (10 mg/kg; ip; single dose) inhibits Bleomycin (HY-108345)-induced lung inflammation and fibrosis in B6 mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 751-03-1
性状 Solid
分子量 454.51
分子式 C₂₆H₃₀O₇
Color White to off-white
SMILES

O=C(OC1(C)C)C=C[C@]([C@@]1([H])C2)(C)[C@@]3([H])CC[C@]4(C)[C@@]([C@H]5C(O[C@H]4C6=COC=C6)=O)(O5)[C@]3(C)C2=O
別名

Obacunone
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
- Plants
- Rutaceae
- Citrus
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

All Cell Proliferation/Viability AssayIFWBRT-PCRHistological Imaging/Staining

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Journal Impact Factor

Int Immunopharmacol

Obacunone inhibits RIPK1/RIPK3/MLKL-mediated necroptosis by suppressing mitochondrial ROS and MIF signaling in intestinal ischemia-reperfusion injury. [Abstract]

2026 Jan 1;168(Pt 2):115901. PMID: 41317539
ACS Omega

Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]

2024 Feb 28;9(10):11870-11882. PMID: 38496939
Mol Med Rep

Obacunone inhibits ferroptosis through regulation of Nrf2 homeostasis to treat diabetic nephropathy. [Abstract]

2025 May;31(5):135. PMID: 40116089

Obacunone purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2025 May;31(5):135. [Abstract]

CCK-8 assay was used to measure the viability of HK-2 cells treatment with Obacunone (OB) solutions at different concentrations (0, 5, 10, 20, 40, 80 and 160 µM).

Obacunone purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2025 May;31(5):135. [Abstract]

Levels of ROS in HK-2 cells from each group were measured using immunofluorescence treated with Obacunone (OB) (20, 40, 80 μM).

Obacunone purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2025 May;31(5):135. [Abstract]

Protein levels of GPX4, ACSL4, SLC7A11 and FTH1 in HK-2 cells from each group were measured using western blotting treated with Obacunone (OB) (20, 40, 80 μM).

Obacunone purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2025 May;31(5):135. [Abstract]

The expression levels of Nrf2 and KEAP1 in HK-2 cells from the Control, HG, HG + Obacunone (OB) 20 µM, HG + OB 40 µM and HG + OB 80 µM groups were assessed using reverse transcription-quantitative PCR.

Obacunone purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2025 May;31(5):135. [Abstract]

Severity of renal pathological damage in each group of rats was observed using hematoxylin and eosin staining treated with Obacunone (OB) (25, 50, 100 mg/kg, p.o.).
J Orthop Surg Res

Obacunone acts as a histone deacetylase 1 inhibitor to limit p38MAPK signaling and alleviate osteoarthritis progression. [Abstract]

2025 May 3;20(1):441. PMID: 40319261

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (220.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2002 mL

11.0009 mL

22.0017 mL

5 mM

0.4400 mL

2.2002 mL

4.4003 mL

10 mM

0.2200 mL

1.1001 mL

2.2002 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.50 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (282 KB)
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COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
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MS (2659 KB)
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IR (2659 KB)
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OR (2659 KB)
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SEC-HPLC (2659 KB)
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取扱説明書 (2659 KB)

参考文献

[1]. Chidambara Murthy KN, et al. Obacunone and obacunone glucoside inhibit human colon cancer (SW480) cells by the induction of apoptosis. Food Chem Toxicol. 2011 Jul;49(7):1616-25. [Content Brief]

[2]. Huang DR, et al. Obacunone protects retinal pigment epithelium cells from ultra-violet radiation-induced oxidative injury. Aging (Albany NY). 2021 Feb 1;13(8):11010-11025. [Content Brief]

[3]. Xu S, et al. Obacunone activates the Nrf2-dependent antioxidant responses. Protein Cell. 2016 Sep;7(9):684-8. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2002 mL	11.0009 mL	22.0017 mL	55.0043 mL
	5 mM	0.4400 mL	2.2002 mL	4.4003 mL	11.0009 mL
	10 mM	0.2200 mL	1.1001 mL	2.2002 mL	5.5004 mL
	15 mM	0.1467 mL	0.7334 mL	1.4668 mL	3.6670 mL
	20 mM	0.1100 mL	0.5500 mL	1.1001 mL	2.7502 mL
	25 mM	0.0880 mL	0.4400 mL	0.8801 mL	2.2002 mL
	30 mM	0.0733 mL	0.3667 mL	0.7334 mL	1.8335 mL
	40 mM	0.0550 mL	0.2750 mL	0.5500 mL	1.3751 mL
	50 mM	0.0440 mL	0.2200 mL	0.4400 mL	1.1001 mL
	60 mM	0.0367 mL	0.1833 mL	0.3667 mL	0.9167 mL
	80 mM	0.0275 mL	0.1375 mL	0.2750 mL	0.6876 mL
	100 mM	0.0220 mL	0.1100 mL	0.2200 mL	0.5500 mL

Keywords

Obacunone

4 Cited Publications

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MedChemExpress（MCE）の使用を引用している文献 Obacunone

生物活性

化学情報

Publications (4)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Obacunone 関連分類

HY-N0428 関連分類