P22D
P22D is a BCR-ABL PROTAC degrader based on Dasatinib (HY-10181), with a DC50 value of approximately 10 nM for the wild-type BCR-ABL protein. P22D cannot degrade the BCR-ABL T315I mutant. P22D has inhibitory activity against K562 cells (wild type), but is ineffective against BaF3-BCR-ABL (T315I) cells. P22D can be used for research on chronic myeloid leukemia and acute lymphocytic leukemia.
(Pink: Bcr-Abl ligand (HY-107447); Blue: Cereblon ligand (HY-14658); Black: linker (HY-180980)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2635386-51-3
- 分子式: C49H58ClN13O10S
- 分子量:1056.58
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
More
生物活性
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Bcr-AblWT 10 nM (DC50) |
Cereblon |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | EC50 |
10 μM
Compound: 10; P22D
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Antiproliferative activity against wild type mouse BA/F3 cells incubated for 3 days by CCK8 assay
Antiproliferative activity against wild type mouse BA/F3 cells incubated for 3 days by CCK8 assay
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[PMID: 32657579] |
化学情報
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CAS 番号 2635386-51-3
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分子量 1056.58
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分子式 C49H58ClN13O10S
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SMILES
O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CC3)C(CCCC4=CN(CCOCCOCCOCCOCCNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)N=N4)=O)=C2)S1)NC8=C(C)C=CC=C8Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
P22D 関連分類
HY-180979 関連分類
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