Picaridin
Based on 3 publication(s) in Google Scholar
Picaridin (Lcaridin) is a broad spectrum arthropod repellent. Picaridin interacts with mosquito and tick olfactory receptor proteins. Picaridin repels Aedes aegypti. Picaridin exhibits considerable antibacterial, anticandidal and antifungal properties.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.30%
- CAS 番号: 119515-38-7
- 分子式: C12H23NO3
- 分子量:229.32
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Picaridin
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生物活性
Picaridin (10-20%) repels Aedes aegypti with a protection duration of 351.5-410.4 min[2].
Picaridin (10%-40%, 24-72 h) exhibits considerable antibacterial, anticandidal and antifungal properties, with MICs of 0.31-2.5% (v/v), MBCs/MFCs of 0.62- >2.5% (v/v)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:P. aeruginosa ATCC 27853, E. coli ATCC 25922, K. pneumoniae ATCC 13883, S. aureus ATCC 29213, Y. enterocolitica ATCC 27729, B. cereus ATCC 33019, P. vulgaris ATCC 13315, S. flexneri ATCC 12022, C. albicans, A. niger, B. cinerea, P. vinaceum
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Concentration:10, 20, 30 and 40 % (v/v)
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Incubation Time:24 h for bacterial strains, 48 h for yeast, 72 h for fungi isolates
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Result:Had stronger antibacterial effect than DEET.
Displayed moderate antifungal characteristics that required at least the concentration of 2.5 % (v/v) for a complete inhibitory effect against yeast and fungi.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 119515-38-7
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性状 Liquid (Density: 1.041±0.06 g/cm3)
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分子量 229.32
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分子式 C12H23NO3
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Color Colorless to light yellow
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SMILES
O=C(N1C(CCCC1)CCO)OC(CC)C
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別名
Lcaridin
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (3)
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Journal Impact Factor
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Most Recent
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ACS Appl Mater Interfaces
Long-Term Insect Repellent Electrospun Microfibers from Recycled Poly(ethylene terephthalate). [Abstract]2023 Sep 27;15(38):44722-44730. PMID: 37708409 -
Int J Mol Sci
Characterization in Effective Stimulation on the Magnitude, Gating, Frequency Dependence, and Hysteresis of INa Exerted by Picaridin (or Icaridin), a Known Insect Repellent. [Abstract]2022 Aug 26;23(17):9696. PMID: 36077093 -
溶剤 & 溶解度
DMSO : 250 mg/mL (1090.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (9.07 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (276 KB)
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- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Jonathan D. Bohbot, et al. Insect Repellents: Modulators of Mosquito Odorant Receptor Activity. PLoS One. 2010; 5(8): e12138. [Content Brief]
[3]. Kalaycı S, et al. Determination of antimicrobial properties of picaridin and DEET against a broad range of microorganisms. World J Microbiol Biotechnol. 2014 Feb;30(2):407-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3607 mL | 21.8036 mL | 43.6072 mL | 109.0180 mL |
| 5 mM | 0.8721 mL | 4.3607 mL | 8.7214 mL | 21.8036 mL | |
| 10 mM | 0.4361 mL | 2.1804 mL | 4.3607 mL | 10.9018 mL | |
| 15 mM | 0.2907 mL | 1.4536 mL | 2.9071 mL | 7.2679 mL | |
| 20 mM | 0.2180 mL | 1.0902 mL | 2.1804 mL | 5.4509 mL | |
| 25 mM | 0.1744 mL | 0.8721 mL | 1.7443 mL | 4.3607 mL | |
| 30 mM | 0.1454 mL | 0.7268 mL | 1.4536 mL | 3.6339 mL | |
| 40 mM | 0.1090 mL | 0.5451 mL | 1.0902 mL | 2.7254 mL | |
| 50 mM | 0.0872 mL | 0.4361 mL | 0.8721 mL | 2.1804 mL | |
| 60 mM | 0.0727 mL | 0.3634 mL | 0.7268 mL | 1.8170 mL | |
| 80 mM | 0.0545 mL | 0.2725 mL | 0.5451 mL | 1.3627 mL | |
| 100 mM | 0.0436 mL | 0.2180 mL | 0.4361 mL | 1.0902 mL |
Picaridin 関連分類
HY-116144 関連分類
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