Piperilate
Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 4546-39-8
- 分子式: C21H25NO3
- 分子量:339.43
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Piperilate (1 mg/kg; i.v.) causes hypotension in rabbit which is not blocked by dichloroisoproterenol or Atropine (HY-B1205)[2].
Piperilate (3 mg/kg; i.v.) decreases respiration and heart rate of test rabbits, blocks the Adrenaline (HY-122304)-induced constriction of an isolated rabbit auricle preparation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino mice (18-22 g)[1]
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Dosage:11.3 mg/kg, 29.42 mg/kg
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Administration:Intraperitoneal injection; single dose
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Result:Showed anticholinergic activity with EC50 values of 11.33 mg/kg (antagonism of oxotremorine induced salivation) and 29.42 mg/kg (antagonism of oxotremorine induced tremor) in mice.
化学情報
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CAS 番号 4546-39-8
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分子量 339.43
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分子式 C21H25NO3
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SMILES
O=C(OCCN1CCCCC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O
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別名
Pipethanate
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Faff J, et al. Therapeutic effects of some cholinolytics in organophosphate intoxications. Arch Toxicol. 1976 Oct 28;36(2):139-46. [Content Brief]
[2]. Tanaka S, et al. [Studies on pharmacological effect of pipethanate. II. Effect of pipethanate on respiration, circulation system and smooth muscle]. Eisei Shikenjo Hokoku. 1971;89:54-8. Japanese. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Piperilate 関連分類
HY-105790 関連分類
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