Pipinib
Pipinib is an ATP-competitive and selective phosphatidylinositol 4-kinase IIIb (PI4KB) inhibitor with an IC50 of 2.2 μM. Pipinib reduces intracellular PI4P levels. Pipinib inhibits GLI-mediated transcription, the expression of Hedgehog target genes, and blocks the trafficking of Smoothened to cilia. Pipinib can be used in the research of basal cell carcinoma and medulloblastoma.
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- CAS 番号: 2380013-55-6
- 分子式: C17H18N4O2S
- 分子量:342.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Pipinib (0.001-10 μM; 96 h) inhibits Purmorphamine (HY-15108)-induced osteogenesis in C3H10T1/2 cells, with an IC50 of 0.6 μM[1].
Pipinib (0.01-100 μM; 48 h) inhibits GLI-mediated transcription in Shh-LIGHT2 cells, with an IC50 of 1.7 μM[1].
Pipinib (0.01-10 μM; 48 h) reduces the Purmorphamine-induced expression of Ptch1 and Gli1 in NIH/3T3 cells, with IC50 values of 3.1 μM and 4.1 μM, respectively[1].
Pipinib (5 μM; 48 h) reduces PI4P levels in NIH/3T3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:C3H10T1/2 mesenchymal progenitor cells
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Concentration:0.001, 0.01, 0.1, 1, 10 μM
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Incubation Time:96 h
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Result:Potently inhibited Purmorphamine-induced osteogenesis, with an IC50 of 0.6 μM.
化学情報
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CAS 番号 2380013-55-6
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分子量 342.42
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分子式 C17H18N4O2S
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SMILES
O=C(C1=CC=C(NC2=NC(NC(C)C)=NC3=C2SC=C3)C=C1)OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Pipinib 関連分類
HY-182721 関連分類
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