PPAR agonist 5
Based on 1 Customer Validation
PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC50 values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect.
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- 純度 : 97.16%
- CAS 番号: 3059387-62-8
- 分子式: C26H29NO3
- 分子量:403.51
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保管条件:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
PPARα 3.20 μM (EC50) |
PPARβ/δ 1.51 μM (EC50) |
PPARγ 1.92 μM (EC50) |
体外実験
PPAR agonist 5 (compound 4b) (10 µM; 4, 24 h) decrease LPS (HY-D1056) induced mRNA expression of CCL-2 and IL-6[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 human monocytes differentiated into macrophages
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Concentration:10 µM
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Incubation Time:4, 24 h
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Result:Decreased the LPS (HY-D1056) (10 ng/mL)-induced expression of CCL-2 at 4 and 24 h and the expression of IL-6 at 24 h.
化学情報
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CAS 番号 3059387-62-8
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性状 Liquid
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分子量 403.51
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分子式 C26H29NO3
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Color Light yellow to brown
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SMILES
O=C(OCC)CC/C(C)=C/CCC1=NC2=CC=C(OCC3=CC=CC=C3)C=C2C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (123.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
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- Deutsch - DE (252 KB)
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- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4783 mL | 12.3913 mL | 24.7825 mL | 61.9563 mL |
| 5 mM | 0.4957 mL | 2.4783 mL | 4.9565 mL | 12.3913 mL | |
| 10 mM | 0.2478 mL | 1.2391 mL | 2.4783 mL | 6.1956 mL | |
| 15 mM | 0.1652 mL | 0.8261 mL | 1.6522 mL | 4.1304 mL | |
| 20 mM | 0.1239 mL | 0.6196 mL | 1.2391 mL | 3.0978 mL | |
| 25 mM | 0.0991 mL | 0.4957 mL | 0.9913 mL | 2.4783 mL | |
| 30 mM | 0.0826 mL | 0.4130 mL | 0.8261 mL | 2.0652 mL | |
| 40 mM | 0.0620 mL | 0.3098 mL | 0.6196 mL | 1.5489 mL | |
| 50 mM | 0.0496 mL | 0.2478 mL | 0.4957 mL | 1.2391 mL | |
| 60 mM | 0.0413 mL | 0.2065 mL | 0.4130 mL | 1.0326 mL | |
| 80 mM | 0.0310 mL | 0.1549 mL | 0.3098 mL | 0.7745 mL | |
| 100 mM | 0.0248 mL | 0.1239 mL | 0.2478 mL | 0.6196 mL |
PPAR agonist 5 関連分類
HY-163547 関連分類
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