PSB-0788
Based on 1 Customer Validation
PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.68%
- CAS 番号: 1027513-54-7
- 分子式: C25H27ClN6O4S
- 分子量:543.04
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Adenosine Receptor アイソフォーム固有の製品をすべて表示
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生物活性
IC50: 3.64 nM (A2BAdoR)[1].
Ki: 0.393 nM (human, A2B); >1000 nM (A3 human recombinant); 333 nM (A2A human recombinant); 1730 nM (A2A rat brain striatal membranes); 2240 nM (A1 human recombinant); 386 nM (A1 rat brain cortical membranes))[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Jurkat | IC50 |
3.64 nM
Compound: 17, PSB-0788
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Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2
Antagonist activity at adenosine A2B receptor in human Jurkat T cells assessed as inhibition of NECA-induced increase in intracellular calcium concentration by fluorimetric measurement in presence of MSX-2
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[PMID: 19569717] |
PSB-0788 (compound 17) has high potency at the A2BAdoR with IC50 value of 3.64 nM[1].
PSB-0788 has good profile of affinity and selectivity (Ki: 0.393 nM (A2B human recombinant); >1000 nM (A3 human recombinant); 333 nM (A2A human recombinant); 1730 nM (A2A rat brain striatal membranes); 2240 nM (A1 human recombinant); 386 nM (A1 rat brain cortical membranes))[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1027513-54-7
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性状 Solid
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分子量 543.04
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分子式 C25H27ClN6O4S
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Color White to off-white
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SMILES
O=C1NC2=C(C(N1CCC)=O)NC(C3=CC=C(S(=O)(N4CCN(CC4)CC5=CC=C(C=C5)Cl)=O)C=C3)=N2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (230.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8415 mL | 9.2074 mL | 18.4149 mL | 46.0371 mL |
| 5 mM | 0.3683 mL | 1.8415 mL | 3.6830 mL | 9.2074 mL | |
| 10 mM | 0.1841 mL | 0.9207 mL | 1.8415 mL | 4.6037 mL | |
| 15 mM | 0.1228 mL | 0.6138 mL | 1.2277 mL | 3.0691 mL | |
| 20 mM | 0.0921 mL | 0.4604 mL | 0.9207 mL | 2.3019 mL | |
| 25 mM | 0.0737 mL | 0.3683 mL | 0.7366 mL | 1.8415 mL | |
| 30 mM | 0.0614 mL | 0.3069 mL | 0.6138 mL | 1.5346 mL | |
| 40 mM | 0.0460 mL | 0.2302 mL | 0.4604 mL | 1.1509 mL | |
| 50 mM | 0.0368 mL | 0.1841 mL | 0.3683 mL | 0.9207 mL | |
| 60 mM | 0.0307 mL | 0.1535 mL | 0.3069 mL | 0.7673 mL | |
| 80 mM | 0.0230 mL | 0.1151 mL | 0.2302 mL | 0.5755 mL | |
| 100 mM | 0.0184 mL | 0.0921 mL | 0.1841 mL | 0.4604 mL |
PSB-0788 関連分類
HY-103165 関連分類
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