キニザリン
Based on 1 Customer Validation
Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.84%
- CAS 番号: 81-64-1
- 分子式: C14H8O4
- 分子量:240.21
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
>30 μg/mL
Compound: DHAQ
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Inhibitory concentration required against A 431 human epidermoid carcinoma cell line
Inhibitory concentration required against A 431 human epidermoid carcinoma cell line
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[PMID: 11354370] |
| A549 | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human A549 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| B16 | IC50 |
>30 μg/mL
Compound: DHAQ
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Inhibitory concentration against B16 murine melanoma cell line
Inhibitory concentration against B16 murine melanoma cell line
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[PMID: 11354370] |
| Ca-Ski | IC50 |
>10 μM
Compound: 1
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Cytotoxicity against human CaSki cells after 72 hrs by MTT assay
Cytotoxicity against human CaSki cells after 72 hrs by MTT assay
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[PMID: 24657570] |
| HCT-116 | IC50 |
>30 μg/mL
Compound: DHAQ
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Inhibitory concentration against HCT 116 human colon cancer cell line
Inhibitory concentration against HCT 116 human colon cancer cell line
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[PMID: 11354370] |
| HeLa | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human HeLa cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| HepG2 | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human HepG2 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| L02 | IC50 |
>200 μM
Compound: Quinizarin
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Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| MCF7 | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human MCF7 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
| MDA-MB-231 | IC50 |
>200 μM
Compound: Quinizarin
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Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
Inhibition of topoisomerase 2 in human MDA-MB-231 cells assessed as reduction in cell growth measured after 72 hrs by MTT assay
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[PMID: 30846253] |
1,4-Dihydroxyanthraquinone (1,4-DHAQ, a fluorophore) doped cellulose (CL) (denoted as 1,4-DHAQ@CL) microporous nanofiber film has been achieved via simple electrospinning and subsequent deacetylating, and used for highly sensitive and selective fluorescence detection of Cu2+ in aqueous solution[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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化学情報
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CAS 番号 81-64-1
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性状 Solid
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分子量 240.21
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分子式 C14H8O4
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Color Orange to red
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SMILES
O=C1C2=C(C=CC=C2)C(C3=C(O)C=CC(O)=C13)=O
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別名
Quinizarin; 1,4-Dihydroxyanthraquinone
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
DMSO : 3.33 mg/mL (13.86 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
- Español - ES (458 KB)
- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Korean - KR (458 KB)
- Portuguese - PT (458 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Verebová V, et al. Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem Biophys Res Commun. 2014;444(1):50-55. [Content Brief]
[2]. Dominic Cheuk, et al. Investigation into solid and solution properties of quinizarin.
[3]. Wang M, et al. Electrospun 1,4-DHAQ-doped cellulose nanofiber films for reusable fluorescence detection of trace Cu2+ and further for Cr3+. Environ Sci Technol. 2012;46(1):367-373. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1630 mL | 20.8151 mL | 41.6302 mL | 104.0756 mL |
| 5 mM | 0.8326 mL | 4.1630 mL | 8.3260 mL | 20.8151 mL | |
| 10 mM | 0.4163 mL | 2.0815 mL | 4.1630 mL | 10.4076 mL |
Quinizarin 関連分類
HY-D0226 関連分類
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