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United States

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製品番号: HY-187736

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R34803

R34803 is an orally effective Microtubule inhibitor and antiparasitic agent. R34803 impedes directional migration by interfering with the cytoplasmic microtubule complex, and causes metaphase arrest to inhibit the growth of cancer cell aggregates while preventing their invasion into other tissues. R34803 exhibits activity against a variety of parasites. R34803 can be used for research on fibrosarcoma and helminthiasis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 64420-40-2
分子式: C₁₈H₁₆FN₃O₄
分子量:357.34

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

R34803 構造式

CAS 番号: 64420-40-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

体外実験

R34803 (1 μg/mL; 2-7 days) prevents invasion of MO₄ mouse fibrosarcoma cells into embryonic chick heart tissue and inhibits growth of the confronting tissues without causing central necrosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Invasion Assay^[1]

View Protocol

Cell Line:

MO₄ mouse fibrosarcoma cell line
Concentration:

1 μg/mL
Incubation Time:

2, 4, 7 days
Result:

Prevented invasion of MO₄ cells into embryonic chick heart tissue.
Inhibited growth of confronting tissues.
Did not cause central necrosis.

化学情報

CAS 番号 64420-40-2
分子量 357.34
分子式 C₁₈H₁₆FN₃O₄
SMILES

O=C(OC)NC1=NC=2C=CC(=CC2N1)C3(OCCO3)C4=CC=C(F)C=C4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell migration
Cell migration is a method that plays an important role in wound healing, cell differentiation, embryonic development, etc.
Cell invasion
Cell invasion is the ability of cells to migrate from one area to another via the extracellular matrix. Cell invasion is the response of normal and cancer cells to chemical and mechanical stimuli. Before migrating to a new region, the extracellular matrix is degraded by proteases within the cell. Cell invasion often occurs during wound repair, vascularization and inflammation, abnormal tissue invasion, and tumor cell metastasis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Storme G, et al. Effect of anticancer agents on invasion of mouse fibrosarcoma cells in vitro. Oncology. 1981;38(3):182-6.

[2]. Restrepo M, et al. Evaluación del R-34803 en el tratamiento de helmintiasis. Acta Med Colomb. 1983;8(4):224-27.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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