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Rademikibart

(別名: CBP-201)
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Based on 1 Customer Validation

Rademikibart (CBP-201) is a human monoclonal antibody targeting IL-4Rα and IL-4Rα inhibitor with a KD of 20.7 pM when binding to human IL-4Rα epitopes. Rademikibart does not bind to IL-4Rα from other species. Rademikibart inhibits IL-4 and IL-13-mediated STAT6 signaling, TF-1 cell proliferation and thymus activation regulated chemokine (TRAC) production. Rademikibart can be used for the research of atopic dermatitis and asthma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 99.13%
  • CAS 番号: 2648260-80-2
  • 分子量:145.36 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Rademikibart
  • Experimental Validation Results for Rademikibart
  • Experimental Validation Results for Rademikibart
  • Rademikibart Chemical Structure
    Rademikibart 構造式
CAS 番号: 2648260-80-2
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized IL-4R alpha/CD124 Protein, Human can bind Rademikibart. The EC50 for this effect is 4.99 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 Ramos cells with Rademikibart (HY-P990090, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Rademikibart Chemical Structure
    1/16
  • Rademikibart
  • Immobilized IL-4R alpha/CD124 Protein, Human can bind Rademikibart. The EC50 for this effect is 4.99 ng/mL.
  • Flow cytometric analysis of 1.5×106 Ramos cells with Rademikibart (HY-P990090, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).