SB 206553
Based on 1 Customer Validation
SB 206553 is a 5-HT2C inverse agonist. SB 206553 can attenuate methamphetamine-seeking in rats. SB 206553 has activity for 5-HT2 receptor ligands in HEK-293 or CHO-K1 cells expressing human recombinant 5-HT2 receptors with pKi values of 5.6 nM (5-HT2A), 7.7 nM (5-HT2B) and 7.8 nM (5-HT2C), respectively. SB 206553 can be used for the research of psychostimulant abuse disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.35%
- CAS 番号: 158942-04-2
- 分子式: C17H16N4O
- 分子量:292.34
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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5-HT Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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5-HT2A Receptor |
5-HT2B Receptor |
5-HT2C Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| GH4-C1 | EC50 |
1.5 μM
Compound: 55, SB-206553
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Agonist activity at human alpha7 nAChR expressed in GH4C1 cells assessed as potentiation of nicotine-induced calcium signal
Agonist activity at human alpha7 nAChR expressed in GH4C1 cells assessed as potentiation of nicotine-induced calcium signal
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[PMID: 21919481] |
化学情報
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CAS 番号 158942-04-2
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性状 Solid
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分子量 292.34
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分子式 C17H16N4O
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Color White to off-white
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SMILES
O=C(N1CCC2=C1C=C3C(N(C)C=C3)=C2)NC4=CC=CN=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
DMSO : 100 mg/mL (342.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4207 mL | 17.1034 mL | 34.2067 mL | 85.5169 mL |
| 5 mM | 0.6841 mL | 3.4207 mL | 6.8413 mL | 17.1034 mL | |
| 10 mM | 0.3421 mL | 1.7103 mL | 3.4207 mL | 8.5517 mL | |
| 15 mM | 0.2280 mL | 1.1402 mL | 2.2804 mL | 5.7011 mL | |
| 20 mM | 0.1710 mL | 0.8552 mL | 1.7103 mL | 4.2758 mL | |
| 25 mM | 0.1368 mL | 0.6841 mL | 1.3683 mL | 3.4207 mL | |
| 30 mM | 0.1140 mL | 0.5701 mL | 1.1402 mL | 2.8506 mL | |
| 40 mM | 0.0855 mL | 0.4276 mL | 0.8552 mL | 2.1379 mL | |
| 50 mM | 0.0684 mL | 0.3421 mL | 0.6841 mL | 1.7103 mL | |
| 60 mM | 0.0570 mL | 0.2851 mL | 0.5701 mL | 1.4253 mL | |
| 80 mM | 0.0428 mL | 0.2138 mL | 0.4276 mL | 1.0690 mL | |
| 100 mM | 0.0342 mL | 0.1710 mL | 0.3421 mL | 0.8552 mL |
SB 206553 関連分類
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