SJF-1528
Based on 1 Customer Validation
SJF-1528 (PROTAC 1) is a potent EGFR PROTAC degrader with DC50 values of 39.2 nM and 736.2 nM for wild-type EGFR in OVCAR8 cells and Exon 20 Ins mutant EGFR in HeLa cells. SJF-1528 also degrades HER2. SJF-1528 promotes ubiquitination and degradation of EGFR and can be used in breast cancer research.
(Pink: EGFR ligand (HY-159047); Blue: VHL ligand (HY-125845); Black: linker (HY-130532)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.86%
- CAS 番号: 2230821-38-0
- 分子式: C55H57ClFN7O8S
- 分子量:1030.60
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保管条件:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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JAK/STAT Compound Library
HY-L008
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Protein Tyrosine Kinase Compound Library
HY-L016
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Anti-Cancer Compound Library
HY-L025
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Anti-Hepatitis C Virus Compound Library
HY-L073
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Anti-Breast Cancer Compound Library
HY-L074
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Anti-Pancreatic Cancer Compound Library
HY-L077
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Angiogenesis-Related Compound Library
HY-L088
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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PROTAC Library
HY-L151
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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Cell Proliferation Compound Library
HY-L201
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High-Throughput Bioactive Compound Library
HY-L205
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-BR-3 | IC50 |
102 nM
Compound: 30
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Antiproliferative activity against human SK-BR-3 cells
Antiproliferative activity against human SK-BR-3 cells
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[PMID: 34656901] |
SJF-1528 (24 h) induces EGFR degradation in OVCAR8 cells, with a DC50 of 39.2 nM, and induces degradation of the FLAG-tagged exon 20 insertion mutant EGFR in HeLa cells, with a DC50 of 736.2 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2230821-38-0
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性状 Solid
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分子量 1030.60
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分子式 C55H57ClFN7O8S
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Color White to off-white
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SMILES
O=C([C@H]1N(C([C@@H](NC(COCCOCCOC2=CC=C(C3=CC4=C(NC5=CC=C(OCC6=CC=CC(F)=C6)C(Cl)=C5)N=CN=C4C=C3)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
DMSO : 103.06 mg/mL (100.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9703 mL | 4.8515 mL | 9.7031 mL | 24.2577 mL |
| 5 mM | 0.1941 mL | 0.9703 mL | 1.9406 mL | 4.8515 mL | |
| 10 mM | 0.0970 mL | 0.4852 mL | 0.9703 mL | 2.4258 mL | |
| 15 mM | 0.0647 mL | 0.3234 mL | 0.6469 mL | 1.6172 mL | |
| 20 mM | 0.0485 mL | 0.2426 mL | 0.4852 mL | 1.2129 mL | |
| 25 mM | 0.0388 mL | 0.1941 mL | 0.3881 mL | 0.9703 mL | |
| 30 mM | 0.0323 mL | 0.1617 mL | 0.3234 mL | 0.8086 mL | |
| 40 mM | 0.0243 mL | 0.1213 mL | 0.2426 mL | 0.6064 mL | |
| 50 mM | 0.0194 mL | 0.0970 mL | 0.1941 mL | 0.4852 mL | |
| 60 mM | 0.0162 mL | 0.0809 mL | 0.1617 mL | 0.4043 mL | |
| 80 mM | 0.0121 mL | 0.0606 mL | 0.1213 mL | 0.3032 mL |
SJF-1528 関連分類
HY-131864 関連分類
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