SMART1
Based on 1 Customer Validation
SMART1 is a highly specific and CRBN-dependent PROTAC that can effectively degrade Smurf1. SMART1 can block the PDK1-Akt signaling pathway in KRAS mutant colorectal cancer. SMART1 can inhibit tumor growth in KRAS mutant colorectal cancer (CRC) xenograft models.
(Pink: Smurf1 ligand (HY-169049); Blue: Cereblon ligand (HY-14658); Black: linker).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.87%
- 分子式: C40H35N9O7
- 分子量:753.76
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
PROTACs アイソフォーム固有の製品をすべて表示
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生物活性
(Pink: Smurf1 ligand (HY-169049); Blue: Cereblon ligand (HY-14658); Black: linker).
化学情報
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性状 Solid
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分子量 753.76
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分子式 C40H35N9O7
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Color Light yellow to green yellow
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SMILES
CNC(C1=NC=CC(OC2=CC=C(C=C2)N3C=C(N=N3)C4=CC(NC(C5CCCN(C5)C6=C7C(N(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O)=CC=C4)=C1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (132.67 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3267 mL | 6.6334 mL | 13.2668 mL | 33.1671 mL |
| 5 mM | 0.2653 mL | 1.3267 mL | 2.6534 mL | 6.6334 mL | |
| 10 mM | 0.1327 mL | 0.6633 mL | 1.3267 mL | 3.3167 mL | |
| 15 mM | 0.0884 mL | 0.4422 mL | 0.8845 mL | 2.2111 mL | |
| 20 mM | 0.0663 mL | 0.3317 mL | 0.6633 mL | 1.6584 mL | |
| 25 mM | 0.0531 mL | 0.2653 mL | 0.5307 mL | 1.3267 mL | |
| 30 mM | 0.0442 mL | 0.2211 mL | 0.4422 mL | 1.1056 mL | |
| 40 mM | 0.0332 mL | 0.1658 mL | 0.3317 mL | 0.8292 mL | |
| 50 mM | 0.0265 mL | 0.1327 mL | 0.2653 mL | 0.6633 mL | |
| 60 mM | 0.0221 mL | 0.1106 mL | 0.2211 mL | 0.5528 mL | |
| 80 mM | 0.0166 mL | 0.0829 mL | 0.1658 mL | 0.4146 mL | |
| 100 mM | 0.0133 mL | 0.0663 mL | 0.1327 mL | 0.3317 mL |
SMART1 関連分類
HY-W998345 関連分類
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