製品番号: HY-136658

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

(別名: SC-1)

1 Cited Publications

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

STAT3-IN-48 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-48 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-48 does not inhibit kinase activity and has anticancer effects.

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純度: 98.64%
CAS 番号: 1313019-65-6
分子式: C₂₁H₁₃ClF₃N₃O₂
分子量:431.80

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

STAT3-IN-48 構造式

CAS 番号: 1313019-65-6

容量

価格（税別）

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数量

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
Publications (1)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

p-STAT3

STAT アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
PLC-PRF-5	IC₅₀	7.5 μM Compound: 1	Cytotoxicity against human PLC/PRF/5 cells assessed as growth inhibition Cytotoxicity against human PLC/PRF/5 cells assessed as growth inhibition	[PMID: 21531053]

体外実験

STAT3-IN-48 (SC-1; 1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells^[1].
STAT3-IN-48 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity^[1].
STAT3-IN-48 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment shows downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:

1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:

48 hours
Result:

Demonstrated dose-dependent suppression of cell viability in all tested breast cancer cells.

Apoptosis Analysis^[1]

Cell Line:

HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:

1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:

36 hours
Result:

Induced potent apoptotic activity.

Western Blot Analysis^[1]

Cell Line:

HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:

1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:

36 hours
Result:

Showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines.

体内実験

STAT3-IN-48 (10 mg/kg; oral gavage; daily; for 28 days; female NCr athymic nude mice) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells ^[1]
Dosage:

10 mg/kg
Administration:

Oral gavage; daily; for 28 days
Result:

Showed efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.

化学情報

CAS 番号 1313019-65-6
性状 Solid
分子量 431.80
分子式 C₂₁H₁₃ClF₃N₃O₂
Color White to off-white
SMILES

O=C(NC1=CC=C(OC2=CC=C(C#N)C=C2)C=C1)NC3=CC=C(Cl)C(C(F)(F)F)=C3
別名

SC-1
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Cancer Manag Res

Inhibition of microRNA-15b-5p Attenuates the Progression of Oral Squamous Cell Carcinoma via Modulating the PTPN4/STAT3 Axis. [Abstract]

2020 Oct 28;12:10559-10572. PMID: 33149666

溶剤 & 溶解度

体外:

DMSO : 250 mg/mL (578.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3159 mL

11.5794 mL

23.1589 mL

5 mM

0.4632 mL

2.3159 mL

4.6318 mL

10 mM

0.2316 mL

1.1579 mL

2.3159 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chun-Yu Liu, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15(4):R63. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3159 mL	11.5794 mL	23.1589 mL	57.8972 mL
	5 mM	0.4632 mL	2.3159 mL	4.6318 mL	11.5794 mL
	10 mM	0.2316 mL	1.1579 mL	2.3159 mL	5.7897 mL
	15 mM	0.1544 mL	0.7720 mL	1.5439 mL	3.8598 mL
	20 mM	0.1158 mL	0.5790 mL	1.1579 mL	2.8949 mL
	25 mM	0.0926 mL	0.4632 mL	0.9264 mL	2.3159 mL
	30 mM	0.0772 mL	0.3860 mL	0.7720 mL	1.9299 mL
	40 mM	0.0579 mL	0.2895 mL	0.5790 mL	1.4474 mL
	50 mM	0.0463 mL	0.2316 mL	0.4632 mL	1.1579 mL
	60 mM	0.0386 mL	0.1930 mL	0.3860 mL	0.9650 mL
	80 mM	0.0289 mL	0.1447 mL	0.2895 mL	0.7237 mL
	100 mM	0.0232 mL	0.1158 mL	0.2316 mL	0.5790 mL

Keywords

STAT3-IN-48

1 Cited Publications

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1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

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MedChemExpress（MCE）の使用を引用している文献 STAT3-IN-48

STAT アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (1)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

STAT3-IN-48 関連分類

HY-136658 関連分類