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製品番号: HY-190554

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STK436742

STK436742 is a TRPV1 channel antagonist. STK436742 has anti-Amyloid-β propagation and anticancer effects. STK436742 can be used for pain research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 610266-79-0
分子式: C₁₈H₁₄N₂O₃
分子量:306.32

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

STK436742 構造式

CAS 番号: 610266-79-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

STK436742 is a TRPV1 channel antagonist. STK436742 has anti-Amyloid-β propagation and anticancer effects. STK436742 can be used for pain research^[1].

IC₅₀ & Target

^[1]

TRPV1

TRP Channel アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC50	4.35 μM	Inhibition of capsaicin-induced TRPV1 calcium influx in HEK293 cells stably expressing TRPV1 assessed by FDSS/μCELL fluorescence Ca2+ assay using Fluo-4 AM after 20 min compound incubation. Inhibition of capsaicin-induced TRPV1 calcium influx in HEK293 cells stably expressing TRPV1 assessed by FDSS/μCELL fluorescence Ca2+ assay using Fluo-4 AM after 20 min compound incubation.	42732743
HEK293	IC50	0.69 μM	Inhibition of capsaicin-induced TRPV1 transmembrane currents in HEK293 cells stably expressing TRPV1 assessed by whole-cell patch-clamp electrophysiology at +100 mV after 1 min compound application. Inhibition of capsaicin-induced TRPV1 transmembrane currents in HEK293 cells stably expressing TRPV1 assessed by whole-cell patch-clamp electrophysiology at +100 mV after 1 min compound application.	42732743

体外実験

STK436742 (0.005-100 μM; 20 min) inhibits Capsaicin (HY-10448)-induced TRPV1 calcium influx in TRPV1-expressing HEK293 cells with an FDSS IC₅₀ of 4.35 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 610266-79-0
分子量 306.32
分子式 C₁₈H₁₄N₂O₃
SMILES

OC1=C2C(C=CC=C2)=CC=C1C(N/N=C/C3=CC=CC(O)=C3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Guo Y, et al. Discovery and mechanism analysis of novel TRPV1 antagonists driven by multi-dimensional virtual screening and dynamic simulation. European journal of medicinal chemistry. 2026 Sep 10;320:119311.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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