country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-122646

Copy Link Print Information

USP7-IN-2

Name: USP7-IN-2
Brand: MedChemExpress
SKU: HY-122646
Price: 1215.00 USD
Availability: InStock
Rating: 5 (1 reviews)

USP7-IN-2 (compound 4) is a non-competitive USP7 inhibitor with an IC₅₀ of 6 nM. USP7-IN-2 causes degradation of MDM2, stabilization of p53 and induction of p21 in multiple cell lines, and can be utilized in cancer research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2196243-57-7
分子式: C₂₉H₃₄N₆O₃
分子量:514.62

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

USP7-IN-2 構造式

CAS 番号: 2196243-57-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Deubiquitinase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
JeKo-1	IC₅₀	>20000 nM Compound: 27	Antiproliferative activity against human JeKo-1 cells harbouring p53 mutant Antiproliferative activity against human JeKo-1 cells harbouring p53 mutant	[PMID: 36306471]
MM1.S	IC₅₀	585.6 nM Compound: ALM4	Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 3 days by SRB assay Antiproliferative activity against human MM1.S cells assessed as inhibition of cell proliferation incubated for 3 days by SRB assay	[PMID: 39133975]
REH	IC₅₀	20.3 nM Compound: 4	Antiproliferative activity against human REH cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay Antiproliferative activity against human REH cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay	[PMID: 39028938]
RS4-11	IC₅₀	>20000 nM Compound: 4	Antiproliferative activity against human RS4-11 cells with shp53 assessed as cell viability measured after 7 days by PMS-MTS assay Antiproliferative activity against human RS4-11 cells with shp53 assessed as cell viability measured after 7 days by PMS-MTS assay	[PMID: 39028938]
RS4-11	IC₅₀	69 nM Compound: 4	Antiproliferative activity against human RS4-11 cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay Antiproliferative activity against human RS4-11 cells with wild type p53 assessed as cell viability measured after 3 days by PMS-MTS assay	[PMID: 39028938]

化学情報

CAS 番号 2196243-57-7
分子量 514.62
分子式 C₂₉H₃₄N₆O₃
SMILES

O=C1C2=NN(C)C(C3=CC=C(CN)C=C3)=C2N=CN1CC4(O)CCN(C(C[C@H](C5=CC=CC=C5)C)=O)CC4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Gavory G, et al. Discovery and characterization of highly potent and selective allosteric USP7 inhibitors. Nat Chem Biol. 2018 Feb;14(2):118-125. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ