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Xirestomig

(別名: ATG-101)
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Based on 1 Customer Validation

Xirestomig (ATG-101) is a tetravalent "2+2″ PD-L1×4-1BB bispecific antibody. Xirestomig binds PD-L1 and 4-1BB concurrently, with a greater affinity for PD-L1, and potently activated 4-1BB+ T cells when cross-linked with PD-L1-positive cells. Xirestomig activates exhausted T cells upon PD-L1 binding. Xirestomig displays potent antitumor activity in numerous in vivo tumor models, including those resistant or refractory to immune checkpoint inhibitors (ICIs).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • 純度: 98.44%
  • CAS 番号: 2756879-35-1
  • 分子量:196.508 kDa
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Xirestomig
  • Experimental Validation Results for Xirestomig
  • Experimental Validation Results for Xirestomig
  • Xirestomig Chemical Structure
    Xirestomig 構造式
CAS 番号: 2756879-35-1
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-lambda-[scFv]2-heavy-lambda

  • 1/16

    Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Xirestomig. The EC50 for this effect is 51.02 ng/mL.

  • 1/16

    Immobilized 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) can bind Xirestomig. The EC50 for this effect is 56.02 ng/mL.

  • Xirestomig Chemical Structure
    1/16
  • Xirestomig
  • Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Xirestomig. The EC50 for this effect is 51.02 ng/mL.
  • Immobilized 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) can bind Xirestomig. The EC50 for this effect is 56.02 ng/mL.
  • IgG1-lambda-[scFv]2-heavy-lambda