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製品番号: HY-162794

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YCH3124

YCH3124 (compound Z33) is a USP7 inhibitor (IC₅₀=41.9 nM) with antitumor activity. YCH3124 has good in vitro antiproliferative activity against various tumor cells including LNCaP (IC₅₀=3.6 nM) and CHP-212 (IC₅₀=9.9 nM). In addition, YCH3124 disrupts cell cycle progression by restricting G1 phase and induces apoptosis in CHP-212 cells.

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分子式: C₃₀H₃₄N₄O₅
分子量:530.61

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

YCH3124 構造式

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

USP7

41.9 nM (IC₅₀)

Deubiquitinase アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
CHP-212	IC₅₀	>10000 nM Compound: Z33; YCH3124	Antiproliferative activity against human CHP-212 cells transfected with p53 siRNA assessed as reduction in cell viability incubated for 5 days by SRB assay Antiproliferative activity against human CHP-212 cells transfected with p53 siRNA assessed as reduction in cell viability incubated for 5 days by SRB assay	[PMID: 39133975]
CHP-212	IC₅₀	19.88 nM Compound: Z33; YCH3124	Antiproliferative activity against human CHP-212 cells transfected with p21 siRNA assessed as reduction in cell viability incubated for 5 days by SRB assay Antiproliferative activity against human CHP-212 cells transfected with p21 siRNA assessed as reduction in cell viability incubated for 5 days by SRB assay	[PMID: 39133975]
CHP-212	IC₅₀	9.9 nM Compound: Z33; YCH3124	Antiproliferative activity against human CHP-212 cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by SRB assay Antiproliferative activity against human CHP-212 cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by SRB assay	[PMID: 39133975]
LNCaP	IC₅₀	40.3 nM Compound: Z33; YCH3124	Antiproliferative activity against human LNCaP cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay Antiproliferative activity against human LNCaP cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay	[PMID: 39133975]
MM1.S	IC₅₀	10.7 nM Compound: Z33; YCH3124	Antiproliferative activity against human MM1.S cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days Antiproliferative activity against human MM1.S cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days	[PMID: 39133975]
MV4-11	IC₅₀	52.3 nM Compound: Z33; YCH3124	Antiproliferative activity against human MV4-11 cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay Antiproliferative activity against human MV4-11 cells harboring wild type TP53 assessed as inhibition of cell proliferation incubated for 5 days by CCK8 assay	[PMID: 39133975]

化学情報

分子量 530.61
分子式 C₃₀H₃₄N₄O₅
SMILES

O=C1N(CC2(O)CCN(C(C[C@@H](C)C3=CC=CC=C3)=O)CC2)C=NC4=C1C=CN4C5=CC=C(OC)C(OC)=C5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Zhen Zhuang, et al. "Discovery of pyrrolo [2, 3-d] pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy." European Journal of Medicinal Chemistry (2024): 116752. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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生物活性
- 製品説明
- IC₅₀ & Target
化学情報
純度とドキュメンテーション
参考文献

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YCH3124

Deubiquitinase アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

YCH3124 関連分類

HY-162794 関連分類