ZX703
ZX703 is a GPX4 PROTAC degrader with a DC50 of 0.135 μM. ZX703 degrades GPX4 via the ubiquitin-proteasome and autophagy-lysosome pathways. ZX703 induces the accumulation of ROS, thereby triggering Ferroptosis. ZX703 can be used in studies related to fibrosarcoma and prostate cancer.
(Pink: GPX4 ligand (HY-100003); Blue: VHL ligand (HY-125845); Black: linker (HY-Y0148)).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C54H67ClN8O9S
- 分子量:1039.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
IC50 & Target
[1]|
GPX4 0.135 μM (DC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-1080 | IC50 |
0.435 μM
Compound: 5i; ZX703
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Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
Antiproliferative activity against human HT-1080 cells assessed as inhibition of cell growth incubated for 24 hrs by CCK-8 assay
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[PMID: 38505849] |
体外実験
ZX703 (24 h) inhibits HT1080 cell growth with an IC50 of 0.435 μM, showing greater potency than analogs with altered linker length or VHL ligand structure[1].
ZX703 inhibits DU145 cell growth with an IC50 of 0.369 μM[1].
ZX703 (0-5 μM; 0-24 h) potently degrades GPX4 in HT1080 cells in vitro in a dose- and time-dependent manner, with a DC50 of 0.135 μM and sustained degradation for at least 24 h[1].
ZX703 (0.25-1.0 μM; 12 h) induces dose-dependent ROS accumulation in HT1080 cells, leading to ferroptosis that can be rescued by the ferroptosis inhibitor Fer-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT1080 cells
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Concentration:0-5 μM (dose-dependent assay); 0.2 μM (time-course assay)
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Incubation Time:0-24 h (time-course assay)
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Result:Induced dose-dependent GPX4 degradation with a DC50 of 0.135 μM and a maximum degradation (Dmax) of 86%.
In the time-course assay, ~50% of GPX4 was degraded after 6 h, over 80% was degraded after 12 h, and degradation activity persisted for at least 24 h.
化学情報
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分子量 1039.68
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分子式 C54H67ClN8O9S
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SMILES
O=C([C@H]1N(C([C@@H](NC(CCCCCCCCCOC2=CC=C(C(C3=CC=C(Cl)C=C3)N4CCN(C(C5=NOC(C)=C5[N+]([O-])=O)=O)CC4)C=C2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC6=CC=C(C7=C(C)N=CS7)C=C6
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ZX703 関連分類
HY-157788 関連分類
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