FCN-338
Based on 1 Customer Validation
FCN-338 (LOXO-338) is an orally active and selective BCL2 inhibitor with an IC50 of 4.5 nM. FCN-338 also exhibits certain inhibitory activity against Bcl-xL, with an IC50 of 49 nM. FCN-338 blocks the BCL2-BAK/BIM interaction and promotes apoptosis in BCL2-dependent hematologic tumor cells. FCN-338 can be used for research on lymphoma and leukemia.
For research use only. We do not sell to patients.
- Purity : 99.33%
- CAS No.: 2248046-39-9
- Formula: C48H48ClN7O7S
- Molecular Weight:902.46
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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BCL2 4.5 nM (IC50) |
Bcl-xL 49 nM (IC50) |
Bak |
Bim |
In Vitro
FCN-338 inhibits RS4;11 ALL cell proliferation with an IC50 of 2 nM[2].
The IC50 of FCN-338 for inhibiting the proliferation of BCL2-independent H146 small cell lung cancer cells is greater than 2000 nM[2].
FCN-338 inhibits the proliferation of AML and ALL cell lines, with IC50 values ranging from 7 nM to 78 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
FCN-338 (once daily) produces dose-dependent tumor growth inhibition in mouse AML xenograft models[2].
FCN-338 (once daily) produces dose-dependent tumor growth inhibition in mouse ALL xenograft models[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2248046-39-9
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Appearance Solid
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Molecular Weight 902.46
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Formula C48H48ClN7O7S
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Color Light yellow to yellow
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SMILES
ClC1=CC=C(C=C1)C(CC(C)(CC2)C)=C2CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(OC6)=C(C([N+]([O-])=O)=C5)N[C@H]6CC7=CC=CC=C7)=O)=O)C(OC8=CN=C9NC=CC9=C8)=C4)CC3
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Synonyms
LOXO-338
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (110.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.1081 mL | 5.5404 mL | 11.0808 mL | 27.7021 mL |
| 5 mM | 0.2216 mL | 1.1081 mL | 2.2162 mL | 5.5404 mL | |
| 10 mM | 0.1108 mL | 0.5540 mL | 1.1081 mL | 2.7702 mL | |
| 15 mM | 0.0739 mL | 0.3694 mL | 0.7387 mL | 1.8468 mL | |
| 20 mM | 0.0554 mL | 0.2770 mL | 0.5540 mL | 1.3851 mL | |
| 25 mM | 0.0443 mL | 0.2216 mL | 0.4432 mL | 1.1081 mL | |
| 30 mM | 0.0369 mL | 0.1847 mL | 0.3694 mL | 0.9234 mL | |
| 40 mM | 0.0277 mL | 0.1385 mL | 0.2770 mL | 0.6926 mL | |
| 50 mM | 0.0222 mL | 0.1108 mL | 0.2216 mL | 0.5540 mL | |
| 60 mM | 0.0185 mL | 0.0923 mL | 0.1847 mL | 0.4617 mL | |
| 80 mM | 0.0139 mL | 0.0693 mL | 0.1385 mL | 0.3463 mL | |
| 100 mM | 0.0111 mL | 0.0554 mL | 0.1108 mL | 0.2770 mL |
FCN-338 Related Classifications
HY-175342 Related Classifications
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