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Cat. No.: HY-119765

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VU0366248

VU0366248 is a mGlu5 negative allosteric modulator.

For research use only. We do not sell to patients.

CAS No.: 1243310-20-4
Formula: C₁₄H₇ClF₂N₂O
Molecular Weight:292.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VU0366248 Chemical Structure

CAS No.: 1243310-20-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

VU0366248 is a mGlu5 negative allosteric modulator^[1].

IC₅₀ & Target

mGluR5

All mGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293-A	IC₅₀	347 nM Compound: 41	Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization	[PMID: 20598884]

Chemical Information

CAS No. 1243310-20-4
Molecular Weight 292.67
Formula C₁₄H₇ClF₂N₂O
SMILES

O=C(C1=CC(F)=CC(C#N)=C1)NC2=CC=CC(Cl)=C2F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Karen J Gregory, et al. Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships. Mol Pharmacol. 2012 Nov;82(5):860-75. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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VU0366248

All mGluR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VU0366248 Related Classifications

HY-119765 Related Classifications