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Cat. No.: HY-W769935

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5-POHSA

5-POHSA is a CD36 and Src kinase modulator acting on taste bud cells, and belongs to the fatty acid esters of hydroxy fatty acids (FAHFA) family. 5-POHSA binds to lingual CD36 to initiate intracellular signaling pathways, activate downstream Src kinase, and rapidly elevate intracellular calcium levels. 5-POHSA interacts with the tongue-brain axis by binding to CD36, so as to ameliorate taste disorders and obesity-related adverse reactions. 5-POHSA is applicable to the research of obesity.

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CAS No.: 2161370-68-7
화학식: C₃₄H₆₄O₄
분자량:536.87

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (261 KB)

5-POHSA Chemical Structure

CAS No.: 2161370-68-7

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Chemical Information
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Biological Activity

제품 설명

All Src Isoforms :

In Vitro

5-POHSA (5-100 μM; 5 min) activates Src kinase in cultured mouse taste bud cells in a concentration-dependent manner^[1].
5-POHSA (20 μM) significantly increases calcium influx in mouse taste bud cells cultured in vitro via a CD36-dependent mechanism; in mock-transfected cells, its combined use with Linoleic acid (HY-N0729) produces a synergistic effect on calcium signals, while this response is attenuated in CD36 siRNA-transfected cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2161370-68-7
분자량 536.87
화학식 C₃₄H₆₄O₄
SMILES

CCCCCCCCCCCCCC(OC(CCCCCCC/C=C\CCCCCC)=O)CCCC(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Muthuswamy K, et al.. FAHFA promotes intracellular calcium signaling via activating the fat taste receptor, CD36 and Src protein kinases in mice taste bud cells. Biochimica et biophysica acta. General subjects. 2024 Dec;1868(12):130722. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vitro
Chemical Information
순도&문서
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5-POHSA

High-Throughput Bioactive Compound Library

All Src Isoforms

Biological Activity

Chemical Information

순도&문서

References

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5-POHSA Related Classifications

HY-W769935 Related Classifications