Lipoamide
Based on 10 publication(s) in Google Scholar
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway.
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- Purity: 99.58%
- CAS No.: 940-69-2
- 화학식: C8H15NOS2
- 분자량:205.34
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보관:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Lipoamide
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell. 2020 May 28;181(5):1062-1079.e30. [Abstract]
- Adv Sci (Weinh). 2024 Jun 26:e2404822. [Abstract]
- Acta Pharmacol Sin. 2023 May;44(5):1051-1065. [Abstract]
- Chin Med. 2025 Dec 10;20(1):215. [Abstract]
- Materials. 2021 Feb 18;14(4):963. [Abstract]
- Funct Integr Genomics. 2026 May 29;26(1):111. [Abstract]
- PLoS One. 2020 Sep 17;15(9):e0239340. [Abstract]
- Theriogenology. 2025 May 3:243:117417. [Abstract]
- University of Saskatchewan. 2020 Jun 22.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Others
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In Vivo Efficacy Study
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Histological Imaging/Staining
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WB
Biological Activity
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Human Endogenous Metabolite |
Lipoamide (10-100 μM; 24 h) can reduce H2O2 or 6-OHDA-induced PC12 cell damage and apoptosis, reduce LDH leakage and Caspase-3 activity[2].
Lipoamide (100 μM; 8 h) also upregulates the expression of Nrf2 in PC12 cells, promotes the nuclear translocation of Nrf2 and downstream gene expression, such as inducing the transcription of Nrf2-regulated antioxidant genes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:10, 50, 100 μM
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Incubation Time:24 h; while cells were cultured with H2O2 or 6-OHDA for 5 h.
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Result:Effectively and dose-dependently rescued PC12 cells from cell injury caused by H2O2 or 6-OHDA.
Significantly restored H2O2 or 6-OHDA-induced LDH leakage.
Dose-dependently improved H2O2- or 6-OHDA-induced cell viability decrease.
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Cell Line:PC12 cells
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Concentration:10, 50, 100 μM
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Incubation Time:2, 4, 8 h; while cells were cultured with H2O2 or 6-OHDA for 5 h.
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Result:Improved the expression of nuclear Nrf2 remarkably, and the peak occurred at 4 h.
Chemical Information
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CAS No. 940-69-2
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Appearance Solid
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분자량 205.34
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화학식 C8H15NOS2
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Color Light yellow to yellow
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SMILES
O=C(N)CCCCC1SSCC1
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Synonyms
(±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (10)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell
2020 May 28;181(5):1062-1079.e30. PMID: 32386547 -
Adv Sci (Weinh)
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron. [Abstract]2024 Jun 26:e2404822. PMID: 38924471
Lipoamide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Jun 26:e2404822. [Abstract]
NTA traces and particle size measurement for these EVs purified from normal and hypoxic cells with or without SGs modulator treatment. Con+Puro indicates the cells treated with 30 µg/mL puromycin for 3 h without stressing; H3h/R0h+Lipo and H3h/R0h+Cyc refer to the cells treated with 30 µM Lipoamide or 200 µg/mL cycloheximide during 3 h of hypoxia without reperfusion.
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Acta Pharmacol Sin
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation. [Abstract]2023 May;44(5):1051-1065. PMID: 36347997
Lipoamide purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 May;44(5):1051-1065. [Abstract]
Diagrammatic representation of the main modes of action of ALM.
Lipoamide purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 May;44(5):1051-1065. [Abstract]
After Lipoamide (50 mg/kg, dissolved in 5% sodium carboxymethylcellulose, by gavage for 8 weeks, 6 days a week) treatment, the db/db mice showed no significant change in blood glucose, while the levels of 24 h urine microalbuminuria, serum triglyceride, and serum cholesterol were significantly decreased.
Lipoamide purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 May;44(5):1051-1065. [Abstract]
After Lipoamide treatment, CD3-positive cells were increased in the interstitium of glomeruli and tubules, suggesting increased inflammatory cell infiltration.
Lipoamide purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 May;44(5):1051-1065. [Abstract]
For in vitro experiments, NRK-52E cells were cultured in NG (5.5 mmol/L) and HG (35 mmol/L) medium and treated with different concentrations of Lipoamide (10, 50, 100 and 200 μmol/L) for 48 h. High glucose increased the expression of Col-III and Vimentin, and decreased the expression of E-cadherin in renal tubular epithelial cells. After Lipoamide intervention, Col-III and Vimentin levels were decreased while E-cadherin level was increased, showing a dose-dependent effect.
Lipoamide purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2023 May;44(5):1051-1065. [Abstract]
Drp1 levels decreased and MFN1 levels increased after Lipoamide (50 mg/kg, dissolved in 5% sodium carboxymethylcellulose, by gavage for 8 weeks, 6 days a week) treatment.
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Chin Med
Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition. [Abstract]2025 Dec 10;20(1):215. PMID: 41372934 -
Materials
Development of Novel Oral Formulations of Disulfide Antioxidants Based on Porous Silica for Controlled Release of the Drugs. [Abstract]2021 Feb 18;14(4):963. PMID: 33670671 -
Funct Integr Genomics
DIA-based proteomic analysis reveals Scutellaria barbata D. Don Exosome-like nanovesicles promote ferroptosis in HCC through Nrf2/SLC7A11/GPX4 pathway. [Abstract]2026 May 29;26(1):111. PMID: 42209785 -
PLoS One
Electrocatalytic CO2 fixation by regenerating reduced cofactor NADH during Calvin Cycle using glassy carbon electrode. [Abstract]2020 Sep 17;15(9):e0239340. PMID: 32941542 -
Theriogenology
Supplementation with lipoamide during in vitro maturation improves bovine oocyte maturation and subsequent embryonic development: potential link to PI3K/AKT signaling. [Abstract]2025 May 3:243:117417. PMID: 40334541 -
용액&용해도
DMSO : ≥ 50 mg/mL (243.50 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.67 mg/mL (3.26 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.38 mg/mL (11.59 mM); Clear solution
This protocol yields a clear solution of ≥ 2.38 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (23.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (10.13 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (273 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. E S Arnér, et al. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. Biochem Biophys Res Commun. 1996 Aug 5;225(1):268-74. [Content Brief]
[2]. Hou Y, et al. Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells. J Agric Food Chem. 2019 Jul 24;67(29):8227-8234. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 4.8700 mL | 24.3499 mL | 48.6997 mL | 121.7493 mL |
| DMSO | 5 mM | 0.9740 mL | 4.8700 mL | 9.7399 mL | 24.3499 mL |
| 10 mM | 0.4870 mL | 2.4350 mL | 4.8700 mL | 12.1749 mL | |
| 15 mM | 0.3247 mL | 1.6233 mL | 3.2466 mL | 8.1166 mL | |
| 20 mM | 0.2435 mL | 1.2175 mL | 2.4350 mL | 6.0875 mL | |
| 25 mM | 0.1948 mL | 0.9740 mL | 1.9480 mL | 4.8700 mL | |
| 30 mM | 0.1623 mL | 0.8117 mL | 1.6233 mL | 4.0583 mL | |
| 40 mM | 0.1217 mL | 0.6087 mL | 1.2175 mL | 3.0437 mL | |
| 50 mM | 0.0974 mL | 0.4870 mL | 0.9740 mL | 2.4350 mL | |
| 60 mM | 0.0812 mL | 0.4058 mL | 0.8117 mL | 2.0292 mL | |
| 80 mM | 0.0609 mL | 0.3044 mL | 0.6087 mL | 1.5219 mL | |
| 100 mM | 0.0487 mL | 0.2435 mL | 0.4870 mL | 1.2175 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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