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Monocrotaline

(Synonyms: Crotaline)
48 Cited Publications
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Based on 48 publication(s) in Google Scholar

Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 µM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].

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  • Purity: 99.96%
  • CAS No.: 315-22-0
  • 화학식: C16H23NO6
  • 분자량:325.36
  • 보관:

    4°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • Monocrotaline Chemical Structure
    Monocrotaline Chemical Structure
  • Experimental Validation Results for Monocrotaline
  • Experimental Validation Results for Monocrotaline
  • Experimental Validation Results for Monocrotaline
  • Experimental Validation Results for Monocrotaline
  • Experimental Validation Results for Monocrotaline
CAS No.: 315-22-0
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  • Monocrotaline Chemical Structure
    Monocrotaline Chemical Structure
    1/16
  • 1/16

    Monocrotaline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 7;10(1):3551.  [Abstract]

    Customer Validation
     CD146 protein expression in lungs with Monocrotaline (MCT, 50 mg/kg, i.p., 21 d)-induced PH in rats.

  • 1/16

    Monocrotaline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 7;10(1):3551.  [Abstract]

    Customer Validation
     CD146 mRNA expression in the lungs of rats during development of Monocrotaline (MCT, 50 mg/kg, i.p., 21 d)-induced PH.

  • 1/16

    Monocrotaline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 7;10(1):3551.  [Abstract]

    Customer Validation
     Representative immunofluorescence of CD146 (red) and αSMA (green) in small pulmonary arteries from rat lungs without or with Monocrotaline (MCT, 50 mg/kg, i.p., 21 d)-induced PH.

  • 1/16

    Monocrotaline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 7;10(1):3551.  [Abstract]

    Customer Validation
     Echocardiography measurements were carried out on anti-CD146- or mIgG-treated rats after 5 weeks of MCT (Monocrotaline, 50 mg/kg, i.p.) to determine PAAT, RVID, RVWT, TAPSE, CO, and CI (n = 10 rats per group).

  • 1/16

    Monocrotaline purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 7;10(1):3551.  [Abstract]

    Customer Validation
     Representative images of H&E and immunofluorescent staining of PAs (20–50 μm or 51–100 μm in diameter) stained with αSMA (green). Monocrotaline treatment (MCT, 50 mg/kg, i.p., 21 d). Scale bar, 50 μm.

  • Monocrotaline