Phytic acid (50% w/w in water)
Based on 2 publication(s) in Google Scholar
Phytic acid (50% w/w in water) (Inositol hexaphosphate) is an orally active compound. Phytic acid can be derived from the seeds of legumes. Phytic acid (50% w/w in water) is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Phytic acid (50% w/w in water) attenuates Aβ oligomers and upregulates autophagy protein. Phytic acid (50% w/w in water) can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research.
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- Purity : 99.60%
- CAS No.: 83-86-3
- 화학식: C6H18O24P6
- 분자량:660.04
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보관:
Solution, -20°C, 2 years
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Phytic acid (50% w/w in water)
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
제품 설명
IC50 & Target
Xanthine oxidase[3]
In Vitro
Phytic acid (0.05%-0.4% (wt/wt), 5 min) and sodium chloride show marked synergistic bactericidal effects against nonadapted and acid-adapted Escherichia coli O157:H7 strains[2].
Phytic acid (1-5 mM, 2-3 h) decreases the integrity of Caco-2 cell monolayers by modulating the TJ proteins' localization and down-regulating the expression levels of TJ proteins, and does not cause cytotoxicity to Caco-2 cells[3].
Phytic acid (48-72 h) provides complete protection against amyloid precursor protein-C-terminal fragment-induced cytotoxicity by attenuating levels of increased intracellular calcium, hydrogen peroxide, superoxide, Aβ oligomers, and moderately upregulated the expression of autophagy (beclin-1) protein in MC65 cells[5].
Phytic acid (≥1 mM) stimulates suicidal human erythrocyte death[6].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2
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Concentration:1, 2, 2.5, 3.5, 5 mM
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Incubation Time:3 h
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Result:Showed over 90% of the cells were viable when IP6 concentrations of 1-5 mM were used during the experiments.
In Vivo
Phytic acid (2%, drinking water, 6 months) improves Alzheimer's pathology (AP180, beclin-1, LC3B, sirtuin 1) in Tg2576 mice[5].
Phytic acid (20 mg/kg, i.p., pretreatment at 5 h before coronary artery occlusion) suppresses ischemia-induced hydroxyl radical generation in rat myocardium[7].
Phytic acid (100?mg/kg/d, gavage, five days a week, 8 weeks) shows protective effects against CCl4-induced liver fibrosis in mice[8].
Phytic acid (4% of rodent chow, diet, 30 days) reduces lipogenic enzyme activities in diabetic rats[9].
Phytic acid (1-2 g/100 g, in water, 13 weeks) shows anticarcinogenic effect in colon carcinoma rats, with 36% (1 g/100 g Phytic acid) and 42% (2 g/100 g Phytic acid) reduction in ACF, respectively[10].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Piglets with an initial BW of 7.40 kg[4]
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Dosage:2% (Phytic acid/food)
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Administration:diet, 21 days
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Result:Did not affect the blood plasma glucose and Na concentrations.
Reduced total potential difference and total short-circuit current.
Did not affect the blood plasma glucose and Na concentrations.
Did not affect the SGLT1 protein expression.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 83-86-3
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Appearance Liquid
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분자량 660.04
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화학식 C6H18O24P6
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Color Colorless to light yellow
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SMILES
O=P(O)(O)O[C@H]([C@H]([C@H](OP(O)(O)=O)[C@H]1OP(O)(O)=O)OP(O)(O)=O)[C@H]([C@H]1OP(O)(O)=O)OP(O)(O)=O
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Synonyms
Inositol hexaphosphate; SNF472 free acid
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Solution, -20°C, 2 years
Publications (2)
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Journal Impact Factor
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Most Recent
용액&용해도
In Vitro:
H2O : 300 mg/mL (454.52 mM; Need ultrasonic)
순도&문서
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Data Sheet (308 KB)
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SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
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Handling Instructions (2659 KB)
References
[1]. Shears SB, et al.Assessing the omnipotence of inositol hexakisphosphate.Cell Signal. 2001 Mar;13(3):151-8. [Content Brief]
[2]. Kim NH, et al. Phytic Acid and Sodium Chloride Show Marked Synergistic Bactericidal Effects against Nonadapted and Acid-Adapted Escherichia coli O157:H7 Strains. Appl Environ Microbiol. 2015 Dec 4;82(4):1040-1049. [Content Brief]
[3]. Fu Q, et al. The effect of phytic acid on tight junctions in the human intestinal Caco-2 cell line and its mechanism. Eur J Pharm Sci. 2015 Dec 1;80:1-8. [Content Brief]
[4]. Woyengo TA, et al. Effect of dietary phytic acid on performance and nutrient uptake in the small intestine of piglets. J Anim Sci. 2012 Feb;90(2):543-9. [Content Brief]
[5]. Anekonda TS, et al. Phytic acid as a potential treatment for alzheimer's pathology: evidence from animal and in vitro models. J Alzheimers Dis. 2011;23(1):21-35. [Content Brief]
[6]. Eberhard M, et al. Effect of phytic acid on suicidal erythrocyte death. J Agric Food Chem. 2010 Feb 10;58(3):2028-33. [Content Brief]
[7]. Obata T, et al. Phytic acid suppresses ischemia-induced hydroxyl radical generation in rat myocardium. Eur J Pharmacol. 2016 Mar 5;774:20-4. [Content Brief]
[9]. Omoruyi FO, et al. The potential benefits and adverse effects of phytic Acid supplement in streptozotocin-induced diabetic rats. Adv Pharmacol Sci. 2013;2013:172494. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 1.5151 mL | 7.5753 mL | 15.1506 mL | 37.8765 mL |
| 5 mM | 0.3030 mL | 1.5151 mL | 3.0301 mL | 7.5753 mL | |
| 10 mM | 0.1515 mL | 0.7575 mL | 1.5151 mL | 3.7876 mL | |
| 15 mM | 0.1010 mL | 0.5050 mL | 1.0100 mL | 2.5251 mL | |
| 20 mM | 0.0758 mL | 0.3788 mL | 0.7575 mL | 1.8938 mL | |
| 25 mM | 0.0606 mL | 0.3030 mL | 0.6060 mL | 1.5151 mL | |
| 30 mM | 0.0505 mL | 0.2525 mL | 0.5050 mL | 1.2625 mL | |
| 40 mM | 0.0379 mL | 0.1894 mL | 0.3788 mL | 0.9469 mL | |
| 50 mM | 0.0303 mL | 0.1515 mL | 0.3030 mL | 0.7575 mL | |
| 60 mM | 0.0253 mL | 0.1263 mL | 0.2525 mL | 0.6313 mL | |
| 80 mM | 0.0189 mL | 0.0947 mL | 0.1894 mL | 0.4735 mL | |
| 100 mM | 0.0152 mL | 0.0758 mL | 0.1515 mL | 0.3788 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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