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Cat. No.: HY-184703

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Antidiabetic agent 9

Antidiabetic agent 9 is an orally active antidiabetic agent. Antidiabetic agent 9 promotes the translocation of GLUT4 to the cell surface, activates the AMPK signaling pathway, and has no effect on the PI-3-K/AKT signaling pathway. Antidiabetic agent 9 reduces blood glucose levels in Streptozotocin (HY-13753)-induced diabetic rats. Antidiabetic agent 9 can be used in the research of diabetes.

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화학식: C₂₉H₂₉ClN₄O₅
분자량:549.02

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Antidiabetic agent 9 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

GLUT4

All GLUT Isoforms :

All AMPK Isoforms :

In Vitro

Antidiabetic agent 9 (Compound 6c) (5-25 μM; 16 h) stimulates GLUT4 translocation to the cell surface in differentiated L6-GLUT4myc myotubes in a concentration-dependent manner, with a 1.64-fold increase at 10 μM^[1].
Antidiabetic agent 9 (10 μM; 16 h) activates AMPK signaling via increased phosphorylation of AMPKα at Thr-172 in differentiated L6-GLUT4myc myotubes, and this activation is suppressed by dorsomorphin^[1].
Antidiabetic agent 9 (10 μM; 16 h) increases GLUT4 mRNA expression in differentiated L6 myotubes without affecting AKT2 or IRS1 mRNA levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

differentiated L6 rat skeletal muscle myotubes
Concentration:

10 μM
Incubation Time:

16 h
Result:

Increased GLUT4 mRNA expression relative to control.
Left mRNA expression levels of AKT2 and IRS1 unchanged.

In Vivo

Antidiabetic agent 9 (Compound 6c) (100 mg/kg; p.o.; single administration) significantly reduces blood glucose levels in streptozotocin-induced diabetic male Sprague Dawley rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague Dawley (male, 160 g, streptozotocin-induced diabetic)^[1]
Dosage:

100 mg/kg
Administration:

p.o.; single dose
Result:

Reduced blood glucose levels by 23.9% 5 hours post-treatment.
Significantly lowered the area under the blood glucose vs. time curve (AUC) compared to the diabetic control group.

Chemical Information

분자량 549.02
화학식 C₂₉H₂₉ClN₄O₅
SMILES

ClC1=CC(N2C(NC(C(C3C4=CC=CO4)=C(C)NC5=C3C(CC(C)(C)C5)=O)=O)=C(C(OCC)=O)C=N2)=CC=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Katiyar S, et al. Design, synthesis, and antidiabetic evaluation of Hantzsch's 1,4-dihydropyridine-pyrazole scaffolds as stimulator of skeletal-muscle GLUT4 translocation. Bioorganic chemistry. 2026 Jun 17;180:110110. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Molecular Weight Molecular Weight

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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Antidiabetic agent 9

All GLUT Isoforms

All AMPK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Antidiabetic agent 9 Related Classifications

HY-184703 Related Classifications