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Cat. No.: HY-N21832

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Aplysinol

Aplysinol is an orally active TLR4 signaling pathway inhibitor. Aplysinol reduces the expression of CD14, MyD88, and NF-κB p65, and downregulates the expression and secretion of TNF-α protein as well as the secretion of IL-1β. Aplysinol restores the phagocytic activity of Kupffer cells and reduces plasma endotoxin levels. Aplysinol alleviates alcohol-induced liver histopathological changes and inhibits the elevation of liver injury biomarkers, and can be used for research related to alcoholic liver disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 6790-64-3
화학식: C₁₅H₁₉BrO₂
분자량:311.22

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aplysinol Chemical Structure

CAS No.: 6790-64-3

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

TLR4

All Toll-like Receptor (TLR) Isoforms :

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 15974618]
Bel-7402	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human Bel7402 cells by MTT assay Cytotoxicity against human Bel7402 cells by MTT assay	[PMID: 15974618]
BGC-823	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human BGC823 cells by MTT assay Cytotoxicity against human BGC823 cells by MTT assay	[PMID: 15974618]
HCT-8	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human HCT8 cells by MTT assay Cytotoxicity against human HCT8 cells by MTT assay	[PMID: 15974618]
HeLa	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 15974618]

In Vitro

Aplysinol can be isolated from the dietary-derived metabolites of the red alga Laurencia okamurai^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 6790-64-3
분자량 311.22
화학식 C₁₅H₁₉BrO₂
SMILES

C(O)[C@]12[C@](C)(C=3C(O1)=CC(C)=C(Br)C3)CC[C@@H]2C
Structure Classification
- Others
Initial Source
- Marine natural products
- Marine algae
the Red Alga Laurencia tristicha
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chang Z, et al. Protective effect and underlying mechanism of aplysin on ethanol-induced liver injury in Rats[J]. Food Science, 2020, 41(7): 131-139.

[2]. Palaniveloo K, et al. Halogenated metabolites from the diet of Aplysia dactylomela Rang[J]. Molecules, 2020, 25(4): 815.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Aplysinol

All Toll-like Receptor (TLR) Isoforms

All NF-κB Isoforms