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Cat. No.: HY-171925

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BI-1124

BI-1124 is a cathepsin S inhibitor that exhibits simulated sufficient ocular pharmacokinetic-pharmacodynamic coverage in rabbit models via topical ocular administration. BI-1124 can be used for the research of age-related dry eye disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 752237-69-7
화학식: C₂₂H₃₉N₅O₃
분자량:421.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

BI-1124 Chemical Structure

CAS No.: 752237-69-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

cathepsin S

All Cathepsin Isoforms :

In Vitro

BI-1124 (0.075 mg/mL, 0.0075% w/v) exhibits high corneal permeability, sufficient solubility, and a suitable partition coefficient at pH 7.4 in in silico ADMET and ocular pharmacokinetic analyses. After simulated topical administration, its concentrations in rabbit cornea and conjunctiva can remain sustained above the in vitro IC₅₀ (7 nM) and IC₉₀ (70 nM) levels, which supports its potential to be repurposed for age-related dry eye disease through the inhibition of cathepsin S^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 752237-69-7
분자량 421.59
화학식 C₂₂H₃₉N₅O₃
SMILES

N(C([C@@H](NC(=O)N1CCOCC1)CCC(C)(C)C)=O)C2(C#N)CCN(CCC)CC2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Baltazar B, et al. In silico simulation models for preclinical pharmacokinetic profiling in drug repositioning of a cathepsin S inhibitor for age-related dry eye. Investigative Ophthalmology & Visual Science. 2024 Jun 17;65(7):6124-.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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BI-1124

All Cathepsin Isoforms