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Cat. No.: HY-P991402

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BI-1910

Name: BI-1910
Brand: MedChemExpress
SKU: HY-P991402
Price: 400.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

BI-1910 is an agonistic human IgG2 monoclonal antibody targeting TNFR2, which selectively binds to human TNFR2 without inhibiting TNF-α binding. As an endogenous agonist, BI-1910 activates TNFR2 and mediates the activation of the NF-κB signaling pathway. Its agonistic activity is independent of FcγR or cross-linking; it can directly costimulate T cells and NK cells, induce T cell proliferation, and activate tumor-specific CD8+ T cells. BI-1910 exhibits antitumor activity in vivo, and shows an additive antitumor effect when combined with anti-PD-1 (HY-P9902). It can be used in research related to advanced/metastatic non-small cell lung cancer and hepatocellular carcinoma. Recommended isotype control: Human IgG2 lambda, Isotype Control (HY-P991206).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 98.24%
분자량:143.27 kDa

보관:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

BI-1910 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Isotype

Human IgG2 lambda

Recommend Isotype Controls

Human IgG2 lambda, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

TNFRSF1B

All TNF Receptor Isoforms :

All NF-κB Isoforms :

In Vitro

Innate ImmunityCytokines & ChemokinesAdaptive Immunity

Innate Immunity

Cytokines & Chemokines

BI-1910 (15 min) acts as an agonist of NF-κB signaling in TNFR1-deficient NK-925 cells, with enhanced activity in the presence of TNF-α^[1].
BI-1910 (10 μg/mL; 24 h) acts as an agonist to increase IFN-γ production from primary human NK cells^[1].

Adaptive Immunity

BI-1910 (10 μg/mL; 72 h) acts as an intrinsic agonist to promote proliferation of activated primary human CD4⁺ T cells, with activity independent of cross-linking^[1].

Adaptive Immunity

Innate Immunity

Cytokines & Chemokines

BI-1910 (10 μg/mL; 30 min pre-incubation, followed by 72 h co-culture) delivers TNFR2-mediated co-stimulatory activity to CD3/CD28-stimulated primary human T cells co-cultured with TAMs^[1].

Innate Immunity

BI-1910 (6 h) activates NF-κB signaling in TNFR2-expressing Jurkat reporter cells, as measured by GFP expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

primary human CD4+ T cells
Concentration:

10 μg/mL
Incubation Time:

72 h
Result:

Acted as a strong agonist and promoted the proliferation of primary human CD4+ T cells stimulated with plate-bound anti-CD3 and soluble anti-CD28. The agonistic activity was independent of antibody cross-linking.

In Vivo

Anti-cancerAdaptive ImmunityImmune Tolerance & Immunosuppression

Anti-cancer

Adaptive Immunity

Immune Tolerance & Immunosuppression

BI-1910 (40 mg/kg; i.p.) elicits potent anti-tumor activity in human TNFR2 knock-in mice bearing MC38 tumors, characterized by enhanced CD8⁺ T cell responses and reduced T cell exhaustion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J B-hTNFR2 (human TNFR2 knock-in) (female)

Female B-hTNFR2 knock-in mice (C57BL/6J background), 6-8 weeks old, were subcutaneously inoculated with 0.5 × 10⁶ or 1 × 10⁶ MC38 colon cancer cells suspended in 100 μL PBS into the flank; when tumors reached 40-200 mm³, the mice were randomized into treatment groups based on tumor size and treated via intraperitoneal injection at a dose of 40 mg/kg in a volume of 200 μL.
^[1]
Dosage:

40 mg/kg
Administration:

i.p.
Result:

Increased tumor-infiltrating CD8⁺ T cells on day 8 post-treatment.
Reduced CD8⁺ T cell exhaustion (measured by fewer TOX⁺ cells) on day 8 post-treatment.
Increased proliferation of tumor-specific CD8⁺ T cells (measured by antigen-specific dextramers) on day 8 post-treatment.
Induced CD8⁺ T cell proliferation in tumor-draining lymph nodes on day 8 post-treatment.

Related Protocols :

Gene ID

7133 [NCBI]

Accession

P20333

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

신청

ELISA, FACS, Functional assay

Chemical Information

Appearance Liquid
분자량 143.27 kDa
Color Colorless to light yellow
SMILES

[BI-1910]
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Mårtensson L, et al. Ligand-Blocking and Agonist Antibodies Targeting TNFR2 Employ Distinct Modes of Action to Induce Antitumor Immunity. Cancer research. 2026 Jul 17. [Content Brief]

[2]. Guerrero T C H, et al. 1073TiP A phase I/IIa first in-human phase I study of BI 1910, a monoclonal antibody agonistic to TNFR2, as a single agent and in combination with pembrolizumab in subjects with advanced solid tumors[J]. Annals of Oncology, 2024, 35: S711.

[3]. Hernandez T, et al. 581 Preliminary phase 1 results of clinical trial investigating BI-1910, a tumor necrosis factor receptor 2 (TNFR2) agonist, in solid tumor cancer patients[J]. Journal for Immunotherapy of Cancer, 2025, 13(Suppl 2): A660-A661.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Conjugated
- Reconsititution
- 신청
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

BI-1910

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

All TNF Receptor Isoforms

All NF-κB Isoforms

Biological Activity

제품 설명

Isotype

Recommend Isotype Controls

Species Reactivity

IC50 & Target

In Vitro

In Vivo

Gene ID

Accession

Conjugated

Reconsititution

신청

Chemical Information

순도&문서

References

Calculators

Help & FAQs

BI-1910 Related Classifications

HY-P991402 Related Classifications

Bioz

Keywords

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