BMS-358233
PU3 is a small molecule inhibitor of Hsp90 that competes with geldanamycin for Hsp90. PU3 induces degradation of proteins, including Her2, similar to geldanamycin. PU3 inhibits the growth of breast cancer cells, causing retinoblastoma protein hypophosphorylation, G1 arrest, and differentiation. PU3 represents a novel class of synthetic compounds that bind to Hsp90 and inhibit the proliferation of cancer cells. PU3 could provide a new strategy for the treatment of cancers.
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- CAS No.: 601519-75-9
- 화학식: C25H25ClN6O2S
- 분자량:509.02
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
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Help & FAQs
Biological Activity
HSP90[1]
Chemical Information
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CAS No. 601519-75-9
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분자량 509.02
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화학식 C25H25ClN6O2S
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SMILES
O=C(C1=CC=C2N=C(NC3=NC(NC[C@@H]4OCCC4)=NC(C)=C3)SC2=C1)NC5=C(C)C=CC=C5Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-358233 Related Classifications
HY-120625 Related Classifications
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