Creatinine-d3
Based on 5 publication(s) in Google Scholar
Creatinine-d3 is a deuterium labeled Creatinine. Creatinine (NSC13123) is an orally active, blood-brain barrier-permeable modulator of GABAA and NMDA receptors, with activities of antioxidation and metabolic regulation. Creatinine is generated via non-enzymatic conversion of creatine and phosphocreatine in muscle. Creatinine serum levels correlate with muscle mass, glomerular filtration rate, and extrarenal clearance, serving as an evaluation biomarker for renal function, muscle mass, and clinical outcomes, and used for perioperative renal risk assessment. In addition, Creatinine can induce specific Cryptococcus species to produce creatinine deiminase and act as their nitrogen source, while it can be secreted via renal tubules. Creatinine is widely used in research related to various diseases such as neurodegenerative diseases, psychiatric disorders, acute kidney injury, chronic kidney disease, and renal failure.
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- Purity: 99.90%
- CAS No.: 143827-20-7
- 화학식: C4H4D3N3O
- 분자량:116.14
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Creatinine-d3
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Biological Activity
Human Endogenous Metabolite[1]
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 143827-20-7
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Unlabeled Cas 60-27-5
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Appearance Solid
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분자량 116.14
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화학식 C4H4D3N3O
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Color White to off-white
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SMILES
O=C1N=C(N)N(C([2H])([2H])[2H])C1
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Synonyms
NSC13123-d3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Phytomedicine
The hidden potential of solasonine: Targeting non-small cell lung cancer (NSCLC) metastasis through GATM and Smad2 pathways. [Abstract]2025 Feb 2:139:156455. PMID: 39922150 -
Biomed Pharmacother
Pharmacokinetic profiling of ZCL-278, a cdc42 inhibitor, and its effectiveness against chronic kidney disease. [Abstract]2024 Aug 23:179:117329. PMID: 39180793 -
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Mol Metab
Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle. [Abstract]2025 Jun 19:102191. PMID: 40543756 -
J Chromatogr B Analyt Technol Biomed Life Sci
Simultaneous determination of choline, L-carnitine, betaine, trimethylamine, trimethylamine N-oxide, and creatinine in plasma, liver, and feces of hyperlipidemic rats by UHPLC-MS/MS. [Abstract]2024 Jun 25:1243:124210. PMID: 38936270
용액&용해도
H2O : 25 mg/mL (215.26 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Fang J, et al. Creatinine promotes adipose tissue wasting in chronic kidney disease via creatine and futile creatine cycle. Mol Metab. 2025;98:102191. [Content Brief]
[2]. Allen PJ, et al. Creatine metabolism and psychiatric disorders: Does creatine supplementation have therapeutic value?. Neurosci Biobehav Rev. 2012;36(5):1442-1462. [Content Brief]
[3]. Polacheck I, et al. Creatinine metabolism in Cryptococcus neoformans and Cryptococcus bacillisporus. J Bacteriol. 1980;142(1):15-20. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.6103 mL | 43.0515 mL | 86.1030 mL | 215.2574 mL |
| 5 mM | 1.7221 mL | 8.6103 mL | 17.2206 mL | 43.0515 mL | |
| 10 mM | 0.8610 mL | 4.3051 mL | 8.6103 mL | 21.5257 mL | |
| 15 mM | 0.5740 mL | 2.8701 mL | 5.7402 mL | 14.3505 mL | |
| 20 mM | 0.4305 mL | 2.1526 mL | 4.3051 mL | 10.7629 mL | |
| 25 mM | 0.3444 mL | 1.7221 mL | 3.4441 mL | 8.6103 mL | |
| 30 mM | 0.2870 mL | 1.4350 mL | 2.8701 mL | 7.1752 mL | |
| 40 mM | 0.2153 mL | 1.0763 mL | 2.1526 mL | 5.3814 mL | |
| 50 mM | 0.1722 mL | 0.8610 mL | 1.7221 mL | 4.3051 mL | |
| 60 mM | 0.1435 mL | 0.7175 mL | 1.4350 mL | 3.5876 mL | |
| 80 mM | 0.1076 mL | 0.5381 mL | 1.0763 mL | 2.6907 mL | |
| 100 mM | 0.0861 mL | 0.4305 mL | 0.8610 mL | 2.1526 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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