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Cat. No.: HY-116065

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CUMI-101

CUMI-101 (compound 8) is a 5-HT_1AR agonist (K_i=0.15 nM) with an EC₅₀ of 0.1 nM in the [35S]GTPγS binding assay. CUMI-101 can be used in the research of neurological diseases.

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CAS No.: 179756-61-7
화학식: C₁₉H₂₇N₅O₃
분자량:373.45

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

CUMI-101 Chemical Structure

CAS No.: 179756-61-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- Cellular Effect
Chemical Information
순도&문서
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Biological Activity

제품 설명

CUMI-101 (compound 8) is a 5-HT_1AR agonist (K_i=0.15 nM) with an EC₅₀ of 0.1 nM in the [35S]GTPγS binding assay. CUMI-101 can be used in the research of neurological diseases^[1].

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.1 nM Compound: 8, CUMI-101	Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry Agonist activity at human 5HT1AR expressed in CHO cells assessed as increase in [35S]GTPgammaS binding by liquid scintillation spectrometry	[PMID: 25182564]
CHO	EC₅₀	0.1 nM Compound: CUMI-101	Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding Partial agonist activity at human 5HT1A receptor expressed in CHO cells assessed as increase in [35S]GTPgammaS binding	[PMID: 23816046]

Chemical Information

CAS No. 179756-61-7
분자량 373.45
화학식 C₁₉H₂₇N₅O₃
SMILES

O=C(N(N=CC1=O)CCCCN2CCN(CC2)C3=CC=CC=C3OC)N1C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kumar J S D, et al. Synthesis and evaluation of arylpiperazines derivatives of 3, 5-dioxo-(2H, 4H)-1, 2, 4-triazine as 5-HT1AR ligands[J]. Bioorganic & medicinal chemistry letters, 2014, 24(19): 4759-4762. [Content Brief]

Calculators

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Concentration Concentration

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Molecular Weight Molecular Weight

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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CUMI-101

All 5-HT Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CUMI-101 Related Classifications

HY-116065 Related Classifications