DHTP
Based on 1 Customer Validation
DHTP is a kinesin-13 family of microtubule depolymerases selective allosteric inhibitor that inhibits kinesin-13 ATPase activity and microtubule depolymerization activity. DHTP inhibits Kif2a and MCAK with IC50 values of 1.2 μM and 4.6 μM, respectively, and does not inhibit other kinesin families. DHTP modulates microtubule dynamics in cells, leading to less dynamic microtubules. DHTP links kinesin-13 overexpression to cancer and Paclitaxel (HY-B0015) resistance. DHTP can be used for the research of cancer.
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- Purity: 99.42%
- CAS No.: 1620225-37-7
- 화학식: C25H21ClN2O6S
- 분자량:512.96
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Kinesin Isoforms
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Biological Activity
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Kif2a 1.2 μM (IC50) |
Kif2c/MCAK 4.6 μM (IC50) |
DHTP (0.01-100 μM) inhibits kinesin-13 ATPase activity selectively (IC50 MCAK=4.6 μM, Kif2a=1.2 μM)[1].
DHTP (5 μM, 10 μM, 20 μM) selectively reduces MCAK-induced microtubule depolymerization rate (74% at 5 μM, 89% at 10 μM) without affecting Eg5-driven gliding[1].
DHTP (10 μM; 15-20 minutes post-treatment) modulates microtubule dynamics in Drosophila S2 cells, increasing pause time and persistent growth while reducing catastrophe frequency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1620225-37-7
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Appearance Solid
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분자량 512.96
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화학식 C25H21ClN2O6S
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Color Light yellow to yellow
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SMILES
C(OC(C)C)(=O)C=1C(N2C(S/C(=C\C3=CC=C(OCC(O)=O)C=C3)/C2=O)=NC1)C4=CC=C(Cl)C=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (97.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9495 mL | 9.7473 mL | 19.4947 mL | 48.7367 mL |
| 5 mM | 0.3899 mL | 1.9495 mL | 3.8989 mL | 9.7473 mL | |
| 10 mM | 0.1949 mL | 0.9747 mL | 1.9495 mL | 4.8737 mL | |
| 15 mM | 0.1300 mL | 0.6498 mL | 1.2996 mL | 3.2491 mL | |
| 20 mM | 0.0975 mL | 0.4874 mL | 0.9747 mL | 2.4368 mL | |
| 25 mM | 0.0780 mL | 0.3899 mL | 0.7798 mL | 1.9495 mL | |
| 30 mM | 0.0650 mL | 0.3249 mL | 0.6498 mL | 1.6246 mL | |
| 40 mM | 0.0487 mL | 0.2437 mL | 0.4874 mL | 1.2184 mL | |
| 50 mM | 0.0390 mL | 0.1949 mL | 0.3899 mL | 0.9747 mL | |
| 60 mM | 0.0325 mL | 0.1625 mL | 0.3249 mL | 0.8123 mL | |
| 80 mM | 0.0244 mL | 0.1218 mL | 0.2437 mL | 0.6092 mL |
DHTP Related Classifications
HY-177898 Related Classifications
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