BIRC5 - baculoviral IAP repeat containing 5 Gene

Also Known as API4; EPR-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 332

About BIRC5

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:78,214,253-78,225,635 (from NCBI)

This gene has 11 transcripts (splice variants), 218 orthologues and 7 paralogues. Biased expression in bone marrow (RPKM 13.2), testis (RPKM 10.8) and 12 other tissues.

Summary

This gene is a member of the inhibitor of Apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

BIRC5 Products (6)

mRNA	Protein	Name
NM_001168.3	NP_001159.2	baculoviral IAP repeat-containing protein 5 isoform 1
NM_001012270.2	NP_001012270.1	baculoviral IAP repeat-containing protein 5 isoform 2
NM_001012271.2	NP_001012271.1	baculoviral IAP repeat-containing protein 5 isoform 3
NM_001012270.2	NP_001012270.1	baculoviral IAP repeat-containing protein 5 isoform 2
NM_001012271.2	NP_001012271.1	baculoviral IAP repeat-containing protein 5 isoform 3
NM_001168.3	NP_001159.2	baculoviral IAP repeat-containing protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	9859993	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16322459	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16291752	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	9859993	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11069302	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	16291752	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	10876248	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16291752	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	18086682	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	18591255	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	9859993	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	10876248	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G2/M transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	9859993	GOA
involved in cell division	IMP IMP: Inferred from mutant phenotype	12805209	GOA
involved in establishment of chromosome localization	IMP IMP: Inferred from mutant phenotype	12805209	GOA
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	12805209	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	12805209	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20826784	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	9256286	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21536684	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	12773388	GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	9859993	GOA
involved in positive regulation of exit from mitosis	IMP IMP: Inferred from mutant phenotype	12805209	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16291752	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	21252625	GOA
involved in protein-containing complex localization	IMP IMP: Inferred from mutant phenotype	16239925	GOA
involved in sensory perception of sound	IEP IEP: Inferred from expression pattern	20627126	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	9859993	GOA
part of chromosome passenger complex	IPI IPI: Inferred from physical interaction	15260989	GOA
located in chromosome, centromeric region	IDA IDA: Inferred from direct assay	11084331	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9256286	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	9859993	GOA
located in cytosol	IDA IDA: Inferred from direct assay	12773388	GOA
located in interphase microtubule organizing center	IDA IDA: Inferred from direct assay	9859993	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	15665297	GOA
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	9859993	GOA
located in midbody	IDA IDA: Inferred from direct assay	9859993	GOA
located in nuclear chromosome	IDA IDA: Inferred from direct assay	16322459	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15665297	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	12773388	GOA
located in spindle microtubule	IDA IDA: Inferred from direct assay	9859993	GOA
part of survivin complex	IPI IPI: Inferred from physical interaction	10949038	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BIRC5 Protein Structure

BIR

0
100
142 a.a.

Protein Preferred Names	Protein Names
baculoviral IAP repeat-containing protein 5	apoptosis inhibitor 4

BIRC5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BIRC5	O15392	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
Intra	BIRC5	O15392	APP	Homo sapiens	P05067-2	Y2H Array	32814053
Intra	BIRC5	O15392	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
Intra	BIRC5	O15392	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	BIRC5	O15392	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	BIRC5	O15392	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	BIRC5	O15392	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	BIRC5	O15392	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	BIRC5	O15392	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	BIRC5	O15392	PINK1	Homo sapiens	Q9BXM7	Y2H Array	32814053
Intra	BIRC5	O15392	PINK1	Homo sapiens	Q9BXM7	Validated Y2H	32814053
Intra	BIRC5	O15392	PINK1	Homo sapiens	Q9BXM7	Y2H Pooling	32814053
Intra	BIRC5	O15392	RAN	Homo sapiens	P62826	Anti Bait CoIP	23251006
Intra	BIRC5	O15392	RAN	Homo sapiens	P62826	Pull Down	23251006
Intra	BIRC5	O15392	RAN	Homo sapiens	P62826	ELISA	23251006
Intra	BIRC5	O15392	RAN	Homo sapiens	P62826	PLA	23251006
Intra	BIRC5	O15392	INCENP	Homo sapiens	Q9NQS7	X-Ray Diffraction	17956729
Intra	BIRC5	O15392	INCENP	Homo sapiens	Q9NQS7	GMS	17956729
Intra	BIRC5	O15392	INCENP	Homo sapiens	Q9NQS7	Anti Tag CoIP	33961781
Intra	BIRC5	O15392	INCENP	Homo sapiens	Q9NQS7	PLA	21051298
Intra	BIRC5	O15392	INCENP	Homo sapiens	Q9NQS7	Anti Bait CoIP	21225229
Intra	BIRC5	O15392	INCENP	Homo sapiens	Q9NQS7	Solution Sedimentation	17956729
Intra	BIRC5	O15392	XPO1	Homo sapiens	O14980	Anti Bait CoIP	17099693
Intra	BIRC5	O15392	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	BIRC5	O15392	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	BIRC5	O15392	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	BIRC5	O15392	AURKC	Homo sapiens	Q9UQB9	Y2H	21988832
Intra	BIRC5	O15392	AURKC	Homo sapiens	Q9UQB9	Anti Tag CoIP	27332895
Intra	BIRC5	O15392	CDK1	Homo sapiens	P06493	Anti Bait CoIP	17681274
Intra	BIRC5	O15392	CDK1	Homo sapiens	P06493	IF	17681274
Intra	BIRC5	O15392	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	BIRC5	O15392	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	BIRC5	O15392	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	BIRC5	O15392	DIABLO	Homo sapiens	Q9NR28	Pull Down	23251006
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	IF	21051298
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	Solution Sedimentation	17956729
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	X-Ray Diffraction	17956729
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	Y2H	20739936
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	Footprinting	17956729
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	PLA	21051298
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	GMS	17956729
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	Anti Tag CoIP	33961781
Intra	BIRC5	O15392	CDCA8	Homo sapiens	Q53HL2	Anti Tag CoIP	28514442
Intra	BIRC5	O15392	AURKB	Homo sapiens	Q96GD4	Protein Kinase Assay	19357306
Intra	BIRC5	O15392	AURKB	Homo sapiens	Q96GD4	Anti Bait CoIP	24571573
Intra	BIRC5	O15392	AURKB	Homo sapiens	Q96GD4	Anti Bait CoIP	17099693
Intra	BIRC5	O15392	AURKB	Homo sapiens	Q96GD4	Anti Tag CoIP	27332895
Intra	BIRC5	O15392	LAMTOR5	Homo sapiens	O43504	Y2H Array	32296183
Intra	BIRC5	O15392	LAMTOR5	Homo sapiens	O43504	Y2H Prey Pooling	32296183
Intra	BIRC5	O15392	CCDC85B	Homo sapiens	Q15834	Validated Y2H	32296183
Intra	BIRC5	O15392	CCDC85B	Homo sapiens	Q15834	Y2H Prey Pooling	32296183
Intra	BIRC5	O15392	CCDC85B	Homo sapiens	Q15834	Y2H Array	32296183
Intra	BIRC5	O15392	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	BIRC5	O15392	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	BIRC5	O15392	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	BIRC5	O15392	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	BIRC5	O15392	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	BIRC5	O15392	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	BIRC5	O15392	GAS2L3	Homo sapiens	Q86XJ1	Anti Bait CoIP	24571573
Intra	BIRC5	O15392	BECN1	Homo sapiens	Q14457	Anti Tag CoIP	20638385
Intra	BIRC5	O15392	BECN1	Homo sapiens	Q14457	Anti Bait CoIP	20638385
Intra	BIRC5	O15392	SNCA	Homo sapiens	P37840	Validated Y2H	32814053
Intra	BIRC5	O15392	SNCA	Homo sapiens	P37840	Y2H Array	32814053
Intra	BIRC5	O15392	SNCA	Homo sapiens	P37840	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BIRC5 Proteins

Cat. No.	상품명	Accession	Purity
HY-P7645	BIRC5 Protein, Human	O15392-1 (M1-D142)	≥ 95%, as determined by reducing SDS-PAGE.

BIRC5 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P80352	Survivin/BIRC5 Antibody (YA045)	WB, ICC/IF, IHC-P, FC	Human, Mouse
HY-P80906	Survivin/BIRC5 Antibody (YA665)	WB, IHC-P	Human, Rat
HY-P83830	Survivin/BIRC5 Antibody (YA3527)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P83830A	Survivin/BIRC5 Antibody (YA3527)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P85731	Survivin/BIRC5 Antibody (YA5423)	WB, IHC-P, ICC/IF	Human, Rat
HY-P86537	Survivin/BIRC5 Antibody (YA6229)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Cervical Intraepithelial Neoplasia	CIN
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Adult Malignant Schwannoma	Adult Mpnst Adult Neurofibrosarcoma
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Hepatoblastoma
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Cystadenocarcinoma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Benign Meningioma	Meningioma, Benign
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Rectum Cancer	Malignant Neoplasm Of Rectum Rectal Cancer Cancer Of Rectum Carcinoma Of Rectum Carcinoma Of The Rectum Malignant Rectal Tumor Malignant Rectum Tumor Malignant Tumor Of Rectum Rectal Carcinoma Rectal Cancers Cancer, Rectal
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Gastrointestinal Carcinoma	Gastrointestinal Neoplasms
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	Cutaneous T-Cell Lymphoma Cutaneous T Cell Lymphoma Lymphoma, T-Cell, Cutaneous Ctcl Lymphoma T-Cell Cutaneous
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Urinary System Disease	Abnormality Of The Urinary System Non-Neoplastic Urinary Tract Disease Urinary Tract Disease Urinary Tract Diseases Urinary Tract Anomaly Urologic Diseases Non-Neoplastic Urinary System Disorder Congenital Malformation Of The Urinary System
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Uterine Adnexa Cancer
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Myeloma, Multiple	Multiple Myeloma Plasma Cell Myeloma Kahler Disease Myelomatosis Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Kahler'S Disease Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-124447	BTYNB		98.0%	Unkown
HY-173025	Nurr1 agonist 12	Agonist	99.62%	Unkown
HY-175352	Nurr1 agonist 14		99.42%	Unkown
HY-RS01513	BIRC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17902	Birc5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24371	Birc5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BIRC5	VGNC	VGNC:26501
Canis familiaris	BIRC5	VGNC	VGNC:38461
Rattus norvegicus	BIRC5	RGD	RGD:70499
Mus musculus	BIRC5	MGD	MGI:1203517
Others	BIRC5	NCBI