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KRT33B - keratin 33B Gene

Also Known as K33B; HA3II; Ha-3II; KRTHA3A; KRTHA3B; hHa3-II

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3884

About KRT33B

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:41,363,498-41,369,813 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 45 orthologues and 68 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the keratin gene family. This gene is one of multiple type I hair keratin genes that are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. As a type I hair keratin, the encoded protein is an acidic protein which heterodimerizes with type II keratins to form hair and nails. There are two isoforms of this protein, encoded by two separate genes, keratin 33A and keratin 33B. [provided by RefSeq, May 2012]

KRT33B Products (1)

mRNA	Protein	Name
NM_002279.5	NP_002270.1	keratin, type I cuticular Ha3-II

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23455924	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hair cycle	IDA IDA: Inferred from direct assay	21916889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KRT33B Protein Structure

Filament

0
100
200
300
404 a.a.

Protein Preferred Names	Protein Names
keratin, type I cuticular Ha3-II	hair keratin, type I Ha3-II

KRT33B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KRT33B	Q14525	NF2	Homo sapiens	P35240	Validated Y2H	32814053
Intra	KRT33B	Q14525	NF2	Homo sapiens	P35240	Y2H Pooling	32814053
Intra	KRT33B	Q14525	NF2	Homo sapiens	P35240	Y2H Array	32814053
Intra	KRT33B	Q14525	RTP5	Homo sapiens	Q14D33	Validated Y2H	32296183
Intra	KRT33B	Q14525	GOLGA6L2	Homo sapiens	Q8N9W4-2	Validated Y2H	32296183
Intra	KRT33B	Q14525	KRT82	Homo sapiens	Q9NSB4	Validated Y2H	32296183
Intra	KRT33B	Q14525	KRT78	Homo sapiens	Q8N1N4	Complementation	32296183
Intra	KRT33B	Q14525	KRT78	Homo sapiens	Q8N1N4	Validated Y2H	32296183
Intra	KRT33B	Q14525	KRT78	Homo sapiens	Q8N1N4	MAPPIT	32296183
Intra	KRT33B	Q14525	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	KRT33B	Q14525	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	KRT33B	Q14525	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	KRT33B	Q14525	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	KRT33B	Q14525	CCDC24	Homo sapiens	Q8N4L8	Validated Y2H	32296183
Intra	KRT33B	Q14525	HAPLN2	Homo sapiens	Q9GZV7	Validated Y2H	32296183
Intra	KRT33B	Q14525	KRT80	Homo sapiens	Q6KB66-2	Validated Y2H	32296183
Intra	KRT33B	Q14525	ATG9A	Homo sapiens	Q7Z3C6-3	Validated Y2H	32296183
Intra	KRT33B	Q14525	KRT72	Homo sapiens	Q14CN4	Validated Y2H	32296183
Intra	KRT33B	Q14525	KRT4	Homo sapiens	P19013	Validated Y2H	25416956
Intra	KRT33B	Q14525	KRT79	Homo sapiens	Q5XKE5	Y2H Array	31515488
Intra	KRT33B	Q14525	KRT79	Homo sapiens	Q5XKE5	Validated Y2H	25416956
Intra	KRT33B	Q14525	KRT79	Homo sapiens	Q5XKE5	Validated Y2H	32296183
Intra	KRT33B	Q14525	KRT79	Homo sapiens	Q5XKE5	Y2H Prey Pooling	25416956
Intra	KRT33B	Q14525	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
Intra	KRT33B	Q14525	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	KRT33B	Q14525	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	KRT33B	Q14525	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	KRT33B	Q14525	NUP58	Homo sapiens	Q9BVL2	Validated Y2H	32296183
Intra	KRT33B	Q14525	KRT71	Homo sapiens	Q3SY84	Validated Y2H	32296183
Intra	KRT33B	Q14525	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	KRT33B	Q14525	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	KRT33B	Q14525	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	KRT33B	Q14525	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	KRT33B	Q14525	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	KRT33B	Q14525	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	KRT33B	Q14525	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	KRT33B	Q14525	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	KRT33B	Q14525	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	KRT33B	Q14525	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	KRT33B	Q14525	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	KRT33B	Q14525	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	KRT33B	Q14525	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	KRT33B	Q14525	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	KRT33B	Q14525	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	KRT33B	Q14525	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	KRT33B	Q14525	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	KRT33B	Q14525	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	KRT33B	Q14525	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	KRT33B	Q14525	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	KRT33B	Q14525	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	KRT33B	Q14525	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	KRT33B	Q14525	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	KRT33B	Q14525	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	KRT33B	Q14525	NDUFV2	Homo sapiens	P19404	Validated Y2H	32814053
Intra	KRT33B	Q14525	NDUFV2	Homo sapiens	P19404	Y2H Array	32814053
Intra	KRT33B	Q14525	NDUFV2	Homo sapiens	P19404	Y2H Pooling	32814053
Intra	KRT33B	Q14525	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	KRT33B	Q14525	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	KRT33B	Q14525	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	KRT33B	Q14525	DUSP21	Homo sapiens	Q9H596	Validated Y2H	32296183
Intra	KRT33B	Q14525	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	KRT33B	Q14525	NUP54	Homo sapiens	Q7Z3B4	Validated Y2H	32296183
Intra	KRT33B	Q14525	SGF29	Homo sapiens	Q96ES7	Validated Y2H	32296183
Intra	KRT33B	Q14525	ABI2	Homo sapiens	Q9NYB9	Validated Y2H	25416956
Intra	KRT33B	Q14525	ABI2	Homo sapiens	Q9NYB9	Y2H Array	25416956
Intra	KRT33B	Q14525	RAMAC	Homo sapiens	Q9BTL3	Validated Y2H	32296183
Intra	KRT33B	Q14525	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	KRT33B	Q14525	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	KRT33B	Q14525	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	KRT33B	Q14525	AQP1	Homo sapiens	P29972	Y2H Prey Pooling	25416956
Intra	KRT33B	Q14525	AQP1	Homo sapiens	P29972	Validated Y2H	25416956
Intra	KRT33B	Q14525	C1orf216	Homo sapiens	Q8TAB5	Validated Y2H	32296183
Intra	KRT33B	Q14525	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	KRT33B	Q14525	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	KRT33B	Q14525	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	KRT33B	Q14525	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	KRT33B	Q14525	PRPH	Homo sapiens	P41219	Y2H Pooling	32814053
Intra	KRT33B	Q14525	PRPH	Homo sapiens	P41219	Validated Y2H	32814053
Intra	KRT33B	Q14525	PRPH	Homo sapiens	P41219	Y2H Array	32814053
Intra	KRT33B	Q14525	SHC3	Homo sapiens	Q92529	Validated Y2H	32296183
Intra	KRT33B	Q14525	KLC4	Homo sapiens	Q9NSK0	Validated Y2H	32296183
Intra	KRT33B	Q14525	RAB26	Homo sapiens	Q9ULW5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Skin Pilomatrix Carcinoma	Pilomatrix Carcinoma Of Skin Malignant Pilomatricoma Pilomatricoma, Malignant
Loose Anagen Hair Syndrome	Loose Anagen Syndrome LAHS
T-Cell Immunodeficiency With Thymic Aplasia	Nezelof Syndrome T-Lymphocyte Deficiency TIDTA Immune Defect Due To Absence Of Thymus Thymic Aplasia Nezelof'S Syndrome Thymic Dysplasia With Normal Immunoglobulins Thymic Aplasia Syndrome T-Lymphocyte Immunodeficiency
Rapidly Involuting Congenital Hemangioma	Rich
Hair Follicle Neoplasm	Hair Matrix Neoplasm Hair Matrix Tumour
Monilethrix	Beaded Hair MNLIX Nodose Hair Moniliform Hair Syndrome
Pilomatrixoma	Pilomatricoma PTR Epithelioma Calcificans Of Malherbe Benign Pilomatricoma Calcifying Epithelioma Of Malherbe Pilomatricoma, Somatic Benign Pilomatrixoma Malherbe Calcifying Epithelioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS07452	KRT33B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KRT33B	MGD	MGI:1309991
Others	KRT33B	NCBI