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Cat. No.: HY-177776

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HDAC-IN-97

HDAC-IN-97 is a PROTAC HDAC6 degrader-6that can be used for synthesis of PROTACs, such as HDAC6 degrader-6 (HY-177758). HDAC6 degrader-6 is a potent HDAC6 PROTAC degrader with anticancer activity.

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CAS No.: 149647-86-9
화학식: C₈H₁₅NO₄
분자량:189.21

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

HDAC-IN-97 Chemical Structure

CAS No.: 149647-86-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

HDAC6

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human HL60 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
HT-29	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human HT-29 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
Jurkat	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human Jurkat JA16 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
K562	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human K562 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
SK-BR-3	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human SK-BR-3 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]
U-937	EC₅₀	>100 μM Compound: 1u	Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay Antiproliferative activity against human U937 cells after 48 hrs by cell titer-glo assay	[PMID: 20218673]

Chemical Information

CAS No. 149647-86-9
분자량 189.21
화학식 C₈H₁₅NO₄
SMILES

O=C(CCCCCCC(O)=O)NO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang K, et al. A Cell-Based Target Engagement Assay for the Identification of Cereblon E3 Ubiquitin Ligase Ligands and Their Application in HDAC6 Degraders. Cell Chem Biol. 2020 Jul 16;27(7):866-876.e8. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

HDAC-IN-97

All HDAC Isoforms

Biological Activity

제품 설명

IC50 & Target

Cellular Effect

Chemical Information

순도&문서

References

Calculators

Help & FAQs

HDAC-IN-97 Related Classifications

HY-177776 Related Classifications

Bioz

Keywords

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