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Cat. No.: HY-182799

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IBA-12

IBA-12 is a IKZF2 molecular glue/PROTAC degrader with a DC₅₀ of 276.2 nM (Jurkat cells) and 461.8 nM (Mino cells), and an IC₅₀ of 179.9 nM. IBA-12 binds to the canonical tryptophan triad pocket of CRBN to form a ternary complex with IKZF2. IBA-12 induces IKZF2 degradation mediated by the CRBN-dependent ubiquitin-proteasome system, with no effect on other CRBN substrates. IBA-12 induces the production of interleukin-2 (IL-2) through degrading IKZF2. IBA-12 is applicable to cancer immunology research.
(Pink: IZKF2 ligand (HY-Y1863); Blue: Cereblon ligand (HY-182807); Black: linker).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₄H₂₅ClN₄O₃
분자량:452.93

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

IBA-12 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IBA-12 is a IKZF2 molecular glue/PROTAC degrader with a DC₅₀ of 276.2 nM (Jurkat cells) and 461.8 nM (Mino cells), and an IC₅₀ of 179.9 nM. IBA-12 binds to the canonical tryptophan triad pocket of CRBN to form a ternary complex with IKZF2. IBA-12 induces IKZF2 degradation mediated by the CRBN-dependent ubiquitin-proteasome system, with no effect on other CRBN substrates. IBA-12 induces the production of interleukin-2 (IL-2) through degrading IKZF2. IBA-12 is applicable to cancer immunology research^[1]. (Pink: IZKF2 ligand (HY-Y1863); Blue: Cereblon ligand (HY-182807); Black: linker).

IC₅₀ & Target^[1]

IKZF2

276.2 nM (DC₅₀)

Cereblon

All PROTACs Isoforms :

All IKZF Family Isoforms :

In Vitro

IBA-12 (0-1000 nM; 24 h) dose-dependently increases IL-2 production in stimulated Jurkat cells, confirming functional modulation of the IKZF2-regulated transcriptional pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

stimulated Jurkat cells
Concentration:

0, 10, 100, 1000 and 1000 nM
Incubation Time:

24 h
Result:

Induced dose-dependent increases in IL-2 production.
Showed statistically significant increases observed at 100 and 1000 nM.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	MRT_0-∞	F	V_ss	CL
Rat^[1]	2 mg/kg	i.v.	2.68 h	0.194 h	1359 ng/mL	3748	2.39 h	/	1.27 L/kg	8.87 mL/min/kg
Rat^[1]	10 mg/kg	p.o.	2.49 h	0.667 h	2540 ng/mL	8339	2.57 h	44.5 %	/	/

Chemical Information

분자량 452.93
화학식 C₂₄H₂₅ClN₄O₃
SMILES

O=C1CCC(N2NC(C=C(C3CCN(CC4=CC(Cl)=CC=C4)CC3)C=C5)=C5C2=O)C(N1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Nie HJ, et al. Indazolone-Based Molecular Glue Degraders as a Tunable Platform for Reprogramming Cereblon Substrate Specificity. bioRxiv. 2026 Mar 17:2026-03.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

IBA-12

All PROTACs Isoforms

All IKZF Family Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

IBA-12 Related Classifications

HY-182799 Related Classifications