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Cat. No.: HY-186165

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KARI 101

KARI 101 is a blood-brain barrier permeable acid sphingomyelinase (ASM) inhibitor. KARI 101 directly inhibits ASM activity and reduces ceramide production. KARI 101 induces Ca²⁺mobilization, activates AMPK and triggers GHSR1α internalization. KARI 101 can be used for the research of Alzheimer's disease.

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CAS No.: 3061559-97-2
화학식: C₁₅H₃₀N₄O₂
분자량:298.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

KARI 101 Chemical Structure

CAS No.: 3061559-97-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All AMPK Isoforms :

All Calcium Channel Isoforms :

All GHSR Isoforms :

GHSR1a

In Vitro

KARI 101 binds to purified acid sphingomyelinase (ASM) protein with high affinity^[1].
KARI 101 inhibits the activity of secretory acid sphingomyelinase (ASM) in the supernatant of fibroblasts from PS1 familial Alzheimer's disease^[1].
KARI 101 acts as a potent GHSR1α agonist in HEK293A cells overexpressing GHSR1α, with an EC₅₀ of 188.5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3061559-97-2
분자량 298.42
화학식 C₁₅H₃₀N₄O₂
SMILES

OCC(C1=CN(CCCCCCCCCC)N=N1)(CO)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Park MH, et al. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice. Proc Natl Acad Sci U S A. 2022;119(3):e2115082119. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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KARI 101

All AMPK Isoforms

All Calcium Channel Isoforms

All GHSR Isoforms

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Keywords

Your Recently Viewed Products

KARI 101

All AMPK Isoforms

All Calcium Channel Isoforms

All GHSR Isoforms

Biological Activity

제품 설명

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KARI 101 Related Classifications

HY-186165 Related Classifications

Bioz

Keywords

Your Recently Viewed Products