Linvoseltamab
Based on 1 Customer Validation
Linvoseltamab (REGN5458) is a bispecific T-cell engager (BiTE) antibody that specifically binds to B cell maturation antigen (BCMA) and CD3 of T cells, thereby directing T cells to multiple myeloma (MM) cells expressing BCMA and activating T cells to kill tumor cells. Linvoseltamab can be used in research of relapsed/refractory multiple myeloma (RRMM).
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- Purity : 99.71%
- CAS No.: 2408319-25-3
- 분자량:145.51 kDa
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보관:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
제품 설명
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
CD3E & TNFRSF17
In Vitro
Linvoseltamab (0.1-10 nM, 48 h) activates NFAT signaling in effector cells, increases the expression of T-cell activation marker CD25, and induces cytotoxicity in BCMA-expressing human plasma cells and multiple myeloma (MM) cells, such as NCI-H929 and MOLP-8[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H929 and MOLP-8
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Concentration:0.1-10 nM
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Incubation Time:48 h
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Result:Inhibited cell viability of NCI-H929 and MOLP-8.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NCI-H929 or MOLP-8 xenograft mouse models[3]
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Dosage:0.4-4 mg/kg
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Administration:iv, twice a week for 7 doses
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Result:Inhibited growth of tumor volume.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
신청
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1×106 Jurkat cells labelling CD3E (red) with Linvoseltamab (HY-P9989). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control.
Chemical Information
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CAS No. 2408319-25-3
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Appearance Liquid
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분자량 145.51 kDa
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Color Colorless to light yellow
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SMILES
[Linvoseltamab]
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Synonyms
REGN5458
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)