Lirimilast
Based on 1 Customer Validation
Lirimilast (BAY 19-8004) is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 49 nM. Lirimilast can be used for the treatment of asthma or chronic obstructive pulmonary disease (COPD). Lirimilast has potently anti-inflammatory properties.
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- Purity: 98.69%
- CAS No.: 329306-27-6
- 화학식: C17H12Cl2N2O6S
- 분자량:443.26
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PDE4 42 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
>10 μM
Compound: BAY-198004
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Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB1 expressed in baculovirus infected insect Sf21 cells
Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB1 expressed in baculovirus infected insect Sf21 cells
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[PMID: 22023548] |
| Sf21 | IC50 |
>10 μM
Compound: BAY-198004
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Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB2 expressed in baculovirus infected insect Sf21 cells
Inhibition of His-tagged catalytic domain Trypanosoma brucei brucei PDEB2 expressed in baculovirus infected insect Sf21 cells
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[PMID: 22023548] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 329306-27-6
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Appearance Solid
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분자량 443.26
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화학식 C17H12Cl2N2O6S
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Color White to off-white
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SMILES
O=C(N)NC1=C(C(C2=CC=C(Cl)C=C2Cl)=O)OC3=CC(OS(=O)(C)=O)=CC=C13
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Synonyms
BAY 19-8004
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (225.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2560 mL | 11.2801 mL | 22.5601 mL | 56.4003 mL |
| 5 mM | 0.4512 mL | 2.2560 mL | 4.5120 mL | 11.2801 mL | |
| 10 mM | 0.2256 mL | 1.1280 mL | 2.2560 mL | 5.6400 mL | |
| 15 mM | 0.1504 mL | 0.7520 mL | 1.5040 mL | 3.7600 mL | |
| 20 mM | 0.1128 mL | 0.5640 mL | 1.1280 mL | 2.8200 mL | |
| 25 mM | 0.0902 mL | 0.4512 mL | 0.9024 mL | 2.2560 mL | |
| 30 mM | 0.0752 mL | 0.3760 mL | 0.7520 mL | 1.8800 mL | |
| 40 mM | 0.0564 mL | 0.2820 mL | 0.5640 mL | 1.4100 mL | |
| 50 mM | 0.0451 mL | 0.2256 mL | 0.4512 mL | 1.1280 mL | |
| 60 mM | 0.0376 mL | 0.1880 mL | 0.3760 mL | 0.9400 mL | |
| 80 mM | 0.0282 mL | 0.1410 mL | 0.2820 mL | 0.7050 mL | |
| 100 mM | 0.0226 mL | 0.1128 mL | 0.2256 mL | 0.5640 mL |
Lirimilast Related Classifications
HY-19672 Related Classifications
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