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Cat. No.: HY-165615

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M&B 4935

M&B 4935 is an orally active Amoebicide. M&B 4935 reduces the levels of *Entamoeba histolytica* parasites in rodents. M&B 4935 can be used for the research of amoebiasis.

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CAS No.: 3613-83-0
화학식: C₁₀H₁₁Cl₂NO₃
분자량:264.10

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

M&B 4935 Chemical Structure

CAS No.: 3613-83-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

M&B 4935 is an orally active Amoebicide. M&B 4935 reduces the levels of *Entamoeba histolytica* parasites in rodents. M&B 4935 can be used for the research of amoebiasis^[1].

All Parasite Isoforms :

In Vitro

Parasitic Infection

M&B 4935 (24 h) exhibits amoebicidal activity against Entamoeba histolytica in vitro when tested as processed caecal extract, reducing the average Parasite Index to 0.3 and clearing 4/6 of test tubes of amoebae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parasitic Infection

M&B 4935 (1.0 g/kg; p.o.; 5 divided doses over 72 hours) exhibits in vivo amoebicidal activity in weanling rats with experimental Entamoeba histolytica caecal infection, reaching 74% of the activity of M&B 4321, and has a single-dose oral LD₅₀ of 1.5 g/kg in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Albino rats (weanling)^[1]
Dosage:

1.0 g/kg (total divided dose); 1.0 g/kg (single dose); 1.5 g/kg (LD50)
Administration:

p.o.; 5 divided doses over 72 hours; single dose
Result:

Demonstrated an in vivo amoebicidal activity of 74 relative to M&B 4321 (set at 100).
Resulted in an average Parasite Index of 0.3 (maximum index = 4.0) and cleared amoebae in 4 out of 6 microtubes at a single oral dose of 1.0 g/kg.
Had a single-dose oral LD50 of 1.5 g/kg in rats.

Chemical Information

CAS No. 3613-83-0
분자량 264.10
화학식 C₁₀H₁₁Cl₂NO₃
SMILES

O=C(N(C1=CC=C(O)C=C1)CCO)C(Cl)Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. KIDD DA, et al. Amoebicidal activity of dichloro-N-2-hydroxy-ethyl-N-p-methylsulphonylbenzylacetamide and some related compounds. Br J Pharmacol Chemother. 1962 Feb;18(1):128-37. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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