Oxelumab
Based on 1 Customer Validation
Oxelumab (R 4930) is a human monoclonal antibody against the OX40 ligand (OX40L). Oxelumab can be used for the research of asthma.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.31%
- CAS No.: 1186098-83-8
- 분자량:145.57 kDa
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
Human IgG1 kappa
Human
TNFSF4/OX40L/CD252
Oxelumab (10 μg/mL; 3 d) represses cell proliferation of NK cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Natural Killer (NK) cell lines
-
Concentration:10 μg/mL
-
Incubation Time:3 days
-
Result:Inhibited cell proliferation of NK cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:NSG mice with PBMCs from UC patients with simple clinical colitis activity index (SCCAI)[1]
-
Dosage:5 and 30 mg/kg
-
Administration:Intraperitoneal injectionon; 5 and 30 mg/kg, once daily, on days 6 and 13
-
Result:Reversed the ethanol-induced colon dilated and the lost of distinct pattern of pellets. Decreased the level of IL-6 and increased the concentrations of glutamic acid. Reduced frequencies of splenic human effector memory T cells and switched B cells.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
-
Human IgG1 kappa
ELISA, FACS, Functional assay
-
Immobilized OX40 Ligand/TNFSF4 Protein, Human (HEK293, HY-P700306) can bind Oxelumab. The EC50 for this effect is 60.57 ng/mL. -
Flow cytometric analysis of 1X106 HUVEC cells with Oxelumab (HY-P99408, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
-
CAS No. 1186098-83-8
-
Appearance Liquid
-
분자량 145.57 kDa
-
Color Colorless to light yellow
-
SMILES
[Oxelumab]
-
Synonyms
R 4930; huMAb OX 40L; Ro 49-89991
-
선적
Shipping with dry ice.
-
Formulation
Please refer to the lot-specific COA for specific buffer information.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
-
Data Sheet (260 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Inhibitory Antibodies User Guide (603 KB)
References
[1]. Youngblood BA, et al. AK002, a Humanized Sialic Acid-Binding Immunoglobulin-Like Lectin-8 Antibody that Induces Antibody-Dependent Cell-Mediated Cytotoxicity against Human Eosinophils and Inhibits Mast Cell-Mediated Anaphylaxis in Mice. Int Arch Allergy Immunol. 2019;180(2):91-102. [Content Brief]
[2]. Kweon S, et al. Expansion of Human NK Cells Using K562 Cells Expressing OX40 Ligand and Short Exposure to IL-21. Front Immunol. 2019 Apr 24;10:879. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Oxelumab Related Classifications
HY-P99408 Related Classifications
Powered by Bioz