Piperitenone oxide
Piperitenone oxide is an orally active monoterpene ketone. Piperitenone oxide can be isolated from the essential oils of plants belonging to Mentha x villosa and Ziziphora clinopodioides. Piperitenone oxide induces differentiation. Piperitenone oxide induces chromosome breakage damage, aneuploidy damage and DNA single-strand breaks. Piperitenone oxide reduces ET-1 levels. Piperitenone oxide exerts antihypertensive effects. Piperitenone oxide can be used in studies related to colon cancer.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 3564-96-3
- 화학식: C10H14O2
- 분자량:166.22
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
제품 설명
In Vitro
Piperitenone oxide (10-150 μM; 24 h) induces chromosome breakage or aneuploidy damage in HepG2 cells, resulting in a statistically significant concentration-dependent increase in micronucleus frequency[2].
Piperitenone oxide (30-150 μM; 24 h) induces single-strand DNA breaks or alkali-labile sites in HepG2 cells, resulting in a statistically significant, concentration-dependent increase in the percentage of DNA tail[2].
Piperitenone oxide (0.03-10 μg/mL; 24 h) dose-dependently inhibits norepinephrine-enhanced ET-1 secretion in primary bovine aortic endothelial cells (BAECs)[3].
Piperitenone oxide (50-100 pmol/L; 24 h) has no effect on NO production in norepinephrine-treated primary bovine aortic endothelial cells (BAECs)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:SHR (male, 12-week-old)[3]
-
Dosage:1 mg/kg; 10 mg/kg; 100 mg/kg
-
Administration:p.o.
-
Result:Reduced systolic blood pressure to 203.1 ± 7.9 mmHg (no significant difference vs.
control SHR) at 1 mg/kg.
Reduced systolic blood pressure to 180.7 ± 8.5 mmHg (p < 0.05 vs.
control SHR) at 10 mg/kg.
Reduced systolic blood pressure to 145.8 ± 7.7 mmHg (p < 0.01 vs.
control SHR) at 100 mg/kg.
Caused a dose-dependent reduction in serum ET-1 levels in SHR.
Chemical Information
-
CAS No. 3564-96-3
-
분자량 166.22
-
화학식 C10H14O2
-
SMILES
O=C1[C@@]2([H])O[C@@]2(C)CC/C1=C(C)/C
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piperitenone oxide Related Classifications
HY-134013 Related Classifications
Powered by Bioz