country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-160506

Copy Link Print Information

PRO-6E

고객리뷰

Based on 1 Customer Validation

PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 μM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker；Pink: ALK/c-Met inhibitor Crizotinib (HY-50878)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.10%
CAS No.: 2353493-69-1
화학식: C₄₂H₄₄Cl₂FN₇O₇
분자량:848.75

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PRO-6E Chemical Structure

CAS No.: 2353493-69-1

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All PROTACs Isoforms :

In Vitro

PRO-6E (0.03-10 μM; 48 h) inhibits the cell growth in MKN-45, SNU-638 cells^[1].
PRO‐6 E (1 μM; over 24 h) facilitates MET degradation in MKN-45 cells^[1].
PRO‐6 E (0.1-1 μM; 48 h) increase in the percentage of G2/M phase cells and decrease in the percentage of S phase cells in MKN-45 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MKN-45, SNU-638 cells
Concentration:

0, 0.03, 0.1, 0.3, 1, 3, 10 μM
Incubation Time:

48 h
Result:

Inhibited the cell growth.

Cell Cycle Analysis^[1]

Cell Line:

MKN-45 cells
Concentration:

0, 0.1, 0.3, 1, 3 μM
Incubation Time:

48 h
Result:

Increased in the percentage of G2/M phase cells and decreased in the percentage of S phase cells.

Western Blot Analysis^[1]

Cell Line:

MKN-45 cells
Concentration:

0, 0.03, 0.1, 0.3, 1, 3 μM
Incubation Time:

12, 24, 36, 48, and 72 h
Result:

facilitated MET degradation over 24 hours.

In Vivo

PRO-6E (oral gavage; 30 mg/kg/day for 15 days) inhibits tumor growth in MKN‐45 cell‐derived xenograft tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

MKN‐45 cell‐derived xenograft tumor model^[1]
Dosage:

30 mg/kg/day for 15 days
Administration:

Oral gavage
Result:

Inhibited tumor growth.

Chemical Information

CAS No. 2353493-69-1
Appearance Solid
분자량 848.75
화학식 C₄₂H₄₄Cl₂FN₇O₇
Color White to off-white
SMILES

O=C1C2=C(OCCCCCCCC(N3CCC(N4C=C(C5=CN=C(N)C(O[C@@H](C6=C(C(F)=CC=C6Cl)Cl)C)=C5)C=N4)CC3)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : ≥ 100 mg/mL (117.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1782 mL

5.8910 mL

11.7820 mL

5 mM

0.2356 mL

1.1782 mL

2.3564 mL

10 mM

0.1178 mL

0.5891 mL

1.1782 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen JJ, et al. Crizotinib-based proteolysis targeting chimera suppresses gastric cancer by promoting MET degradation. Cancer Sci. 2023;114(5):1958-1971. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1782 mL	5.8910 mL	11.7820 mL	29.4551 mL
	5 mM	0.2356 mL	1.1782 mL	2.3564 mL	5.8910 mL
	10 mM	0.1178 mL	0.5891 mL	1.1782 mL	2.9455 mL
	15 mM	0.0785 mL	0.3927 mL	0.7855 mL	1.9637 mL
	20 mM	0.0589 mL	0.2946 mL	0.5891 mL	1.4728 mL
	25 mM	0.0471 mL	0.2356 mL	0.4713 mL	1.1782 mL
	30 mM	0.0393 mL	0.1964 mL	0.3927 mL	0.9818 mL
	40 mM	0.0295 mL	0.1473 mL	0.2946 mL	0.7364 mL
	50 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.5891 mL
	60 mM	0.0196 mL	0.0982 mL	0.1964 mL	0.4909 mL
	80 mM	0.0147 mL	0.0736 mL	0.1473 mL	0.3682 mL
	100 mM	0.0118 mL	0.0589 mL	0.1178 mL	0.2946 mL

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

PRO-6E

Apoptosis Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Orally Active Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

PROTAC Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

All PROTACs Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

PRO-6E

Apoptosis Compound Library

Protein Tyrosine Kinase Compound Library

Anti-Cancer Compound Library

Orally Active Compound Library

Angiogenesis-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

PROTAC Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

All PROTACs Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

PRO-6E Related Classifications

HY-160506 Related Classifications