PS21M
PS21M is a negative control PROTAC degrader derived from CPS-021, as well as an inhibitor of ternary complex formation. PS21M attenuates the interaction with Cereblon ligase, restricting the formation of the PAK4-PROTAC-Cereblon ternary complex and the subsequent degradation of PAK4. PS21M serves as a negative control molecule to verify the degradation mechanism of CPS-021.
(Pink: PAK4 ligand (HY-174822); Blue: Cereblon ligand (HY-W586822); Black: linker).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C53H65N11O7
- 분자량:968.15
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
In Vitro
PS21M (2 μM; 4 h), a methyl-substituted negative control derivative of CPS-021, reduces the ability of CPS-021 to degrade PAK4 protein in MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 human breast cancer cells
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Concentration:2, 5 μM
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Incubation Time:4 h
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Result:Attenuated CPS-021-induced PAK4 degradation, resulting in a PAK4 relative abundance of 1.13 versus the untreated control (set at 1.00).
Chemical Information
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분자량 968.15
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화학식 C53H65N11O7
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SMILES
O=C(C1=CN(C2=NC(N)=NC=C2)C3=C1C=CC(C#CC4(O)CCCCC4)=C3)N5CCN(CC5)CCCCCCCC(N6CCN(CCNC7=CC=CC(C(N8C9CCC(N(C)C9=O)=O)=O)=C7C8=O)CC6)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PS21M Related Classifications
HY-174248 Related Classifications
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