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(±)8(9)-EET

(±)8(9)-EET is one of the main metabolites produced by the metabolism of arachidonic acid (HY-109590) through the cytochrome P450 epoxide pathway. (±)8(9)-EET is an effective substrate for COX-1 and COX-2. (±)8(9)-EET activates PPARα in HEK293 cells and inhibits the activity of NF-κB induced by IL-1β in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of (±)8(9)-EET ([(8S,9R)-EET]) causes vasoconstriction, thereby reducing renal plasma flow and glomerular filtration rate.

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  • CAS No.: 184488-44-6
  • 화학식: C20H32O3
  • 분자량:320.47
  • 보관:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • (±)8(9)-EET Chemical Structure
    (±)8(9)-EET Chemical Structure
CAS No.: 184488-44-6
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  • (±)8(9)-EET Chemical Structure
    (±)8(9)-EET Chemical Structure
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  • (±)8(9)-EET